Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat

Zeynep Aktaş; Ali Cansu; Deniz Erdoǧan; Gülnur Take; Guleser Goktas; Sengul Ozdek; Ayse Serdaroglu

doi:10.1016/j.seizure.2009.02.003

Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat

Zeynep Aktaş, Ali Cansu, Deniz Erdoǧan, Gülnur Take, Guleser Goktas, Sengul Ozdek, Ayse Serdaroglu

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number.

Original language	English (US)
Pages (from-to)	396-399
Number of pages	4
Journal	Seizure
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.seizure.2009.02.003
State	Published - Jul 2009
Externally published	Yes

Keywords

Oxcarbazepine
Retinal ganglion cell
Valproic acid

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.seizure.2009.02.003

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title = "Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat",

abstract = "Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number.",

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author = "Zeynep Akta{\c s} and Ali Cansu and Deniz Erdoǧan and G{\"u}lnur Take and Guleser Goktas and Sengul Ozdek and Ayse Serdaroglu",

year = "2009",

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doi = "10.1016/j.seizure.2009.02.003",

language = "English (US)",

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T1 - Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat

AU - Aktaş, Zeynep

AU - Cansu, Ali

AU - Erdoǧan, Deniz

AU - Take, Gülnur

AU - Goktas, Guleser

AU - Ozdek, Sengul

AU - Serdaroglu, Ayse

PY - 2009/7

Y1 - 2009/7

N2 - Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number.

AB - Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number.

KW - Oxcarbazepine

KW - Retinal ganglion cell

KW - Valproic acid

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Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat

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