Resveratrol inhibits mTOR signaling by targeting DEPTOR

Meilian Liu, Feng Liu

Research output: Contribution to journalShort survey

21 Scopus citations

Abstract

Resveratrol (RSV, trans-3,4,5-Trihydroxystilbene), a type of polyphenol originally found in red wines, shows a great promise for the treatment of cancer, aging, type 2 diabetes and cardiovascular diseases. Recent studies suggest that suppressing the signaling pathway mediated by mTOR, a well-known energy sensor that integrates various hormonal, nutrient and environmental signals to regulate cell growth, metabolism and survival, could play an important role in mediating the beneficial effect of RSV. The underlying mechanisms by which RSV inhibits mTOR signaling remain elusive, but our recent studies show that RSV inhibits amino acid-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1-and AMPK-independent mechanism. RSV treatment has no effect on the expression levels of mTOR, raptor and DEPTOR, but greatly promotes the interaction between mTOR and its inhibitor DEPTOR. Our results reveal a novel mechanism by which RSV inhibits mTOR signaling and its function.

Original languageEnglish (US)
Pages (from-to)382-384
Number of pages3
JournalCommunicative and Integrative Biology
Volume4
Issue number4
DOIs
StatePublished - Jan 1 2011

Keywords

  • AMPK
  • DEPTOR
  • PI3K
  • PIKK
  • Resveratrol
  • Sirt1
  • mTOR

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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