Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9

Yan Li, Junye Liu, Xinping Liu, Kefei Xing, Yun Wang, Fuyang Li, Libo Yao

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Resveratrol (trans-3,4N,-5-trihydroxystilbene), a phytoalexin present in grapes and red wine, is emerging as a natural compound with potential anticancer properties. Here we show that resveratrol affects the growth of human breast cancer cell lines MCF7, MDA-MB-231, SK-BR-3, and Bcap-37 in a dose-dependent manner and that MCF7 is the most sensitive among the four cell lines. MCF7 cells treated with resveratrol showed typical characteristics of apoptosis including the poly (ADP-ribose) polymerase cleavage, TdT-mediated dUTP nick end labeling-positive staining, and morphologic changes. Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on resveratrol treatment. These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalApplied Biochemistry and Biotechnology
Volume135
Issue number3
DOIs
StatePublished - Dec 2006

Keywords

  • Akt
  • Apoptosis
  • Caspase-9
  • MCF7
  • Resveratrol

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology

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