Resuscitation of pulmonary contusion: hypertonic saline is not beneficial

Stephen M. Cohn, Brian T. Fisher, Arthur T. Rosenfield, John H. Cross

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We postulated that hypertonic solutions could minimize the accumulation of lung water and subsequent respiratory derangements that occur after pulmonary contusion. Anesthetized pigs underwent contusion of the right chest at baseline and then were hemorrhaged (30 cc/kg) over 20 min. They were resuscitated with either 7.5% NaCl (4 cc/kg) or .9% saline (90 cc/kg) for 20 min and observed for 4 h. Gravimetric lung weights and spiral computed tomography scans were used to quantitate lung water. The hemodynamic response to contusion and hemorrhage was similar in both resuscitation groups. Arterial oxygen tension was not significantly altered by the method of resuscitation and remained close to baseline values for the entirety of the experiment. Static compliance measurements were significantly decreased from baseline in both groups following pulmonary contusion. There were no differences in wet to dry lung weights or computed tomography scan injury volume between groups. We conclude that small volume hypertonic saline resuscitation does not reduce the magnitude of lung injury or provide substantial physiologic benefit over isotonic solutions following pulmonary contusion.

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalShock
Volume8
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Contusions
Resuscitation
Lung
Hypertonic Solutions
Isotonic Solutions
Weights and Measures
Water
Spiral Computed Tomography
Lung Injury
Compliance
Arterial Pressure
Swine
Thorax
Hemodynamics
Tomography
Hemorrhage
Oxygen
Wounds and Injuries

ASJC Scopus subject areas

  • Physiology
  • Critical Care and Intensive Care Medicine

Cite this

Cohn, S. M., Fisher, B. T., Rosenfield, A. T., & Cross, J. H. (1997). Resuscitation of pulmonary contusion: hypertonic saline is not beneficial. Shock, 8(4), 292-299.

Resuscitation of pulmonary contusion : hypertonic saline is not beneficial. / Cohn, Stephen M.; Fisher, Brian T.; Rosenfield, Arthur T.; Cross, John H.

In: Shock, Vol. 8, No. 4, 1997, p. 292-299.

Research output: Contribution to journalArticle

Cohn, SM, Fisher, BT, Rosenfield, AT & Cross, JH 1997, 'Resuscitation of pulmonary contusion: hypertonic saline is not beneficial', Shock, vol. 8, no. 4, pp. 292-299.
Cohn SM, Fisher BT, Rosenfield AT, Cross JH. Resuscitation of pulmonary contusion: hypertonic saline is not beneficial. Shock. 1997;8(4):292-299.
Cohn, Stephen M. ; Fisher, Brian T. ; Rosenfield, Arthur T. ; Cross, John H. / Resuscitation of pulmonary contusion : hypertonic saline is not beneficial. In: Shock. 1997 ; Vol. 8, No. 4. pp. 292-299.
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