Resuscitation of pulmonary contusion: Effects of a red cell substitute

Stephen M. Cohn, Paul M. Zieg, Arthur T. Rosenfield, Brian T. Fisher

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective: To determine the impact of a vasoactive red cell substitute, diaspirin cross-linked hemoglobin, on respiratory derangements after traumatic lung injury. Design: Randomized, controlled animal experiment. Setting: Large-animal laboratory. Subjects: Mechanically ventilated, anesthetized young Yorkshire male swine (15 to 20 kg). Interventions: Pigs (n = 6/group) received two pneumatic blasts to the right thoracic cage at baseline, were hemorrhaged 30 mL/kg from t = 0 to 20 mins, resuscitated with 0.9% saline (group 1, 90 mL/kg) or diaspirin cross-linked hemoglobin (group 2, 15 mL/kg) from t = 20 to 40 mins, and then observed to t = 240 mins. Measurements and Main Results: Serial pulmonary and systemic hemodynamic measurements, total thoracic compliance assessment, spiral three-dimensional computed tomography scan, and lung weights (n = 3/group) were used to assess lesion size and lung water. Mean arterial pressure was restored in both animal groups. Mean pulmonary arterial pressure was significantly higher after resuscitation in animals receiving the red cell substitute. Oxygenation worsened mildly in both groups. Compliance diminished in both groups but was significantly worse at the end of the experiment in animals infused with diaspirin cross-linked hemoglobin. Right lung weights and right thoracic computed tomography scan volume were higher with diaspirin cross-linked hemoglobin than with saline. Conclusions: After pulmonary contusion, resuscitation with diaspirin cross-linked hemoglobin led to pulmonary hypertension, greater pulmonary contusion lesion size, and stiffer lungs in this porcine model.

Original languageEnglish (US)
Pages (from-to)484-491
Number of pages8
JournalCritical care medicine
Issue number3
StatePublished - Mar 1 1997


  • blood substitutes
  • diaspirin cross-linked hemoglobin
  • hemorrhagic shock
  • pulmonary contusion
  • pulmonary hypertension
  • resuscitation
  • thoracic computed tomography
  • traumatic lung injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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