Restriction of PGK‐B to spermatogenic cells: Evidence from experimentally cryptorchid mice

Natalie S. Rudolph, John L. VandeBerg

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    The hypothesis that PGK‐B, like LDH‐C4, is restricted to spermatogenic cells was explored by examining isozyme patterns in testes from mice depleted of germinal cells by surgical cryptorchism. In experimentally cryptorchized C57BL/10Sn males, decline in PGK‐B activity paralleled decline in LDH‐C4 activity and was correlated with degeneration of spermatocytes, spermatids, and spermatozoa. Trace amounts of these sperm isozymes found in cryptorchid testes after the depletion of maturing germ cells probably came from degenerated spermatids and spermatocytes and not from somatic testicular cells.

    Original languageEnglish (US)
    Pages (from-to)341-353
    Number of pages13
    JournalDevelopmental Genetics
    Volume1
    Issue number4
    DOIs
    StatePublished - 1979

    Keywords

    • LDH‐C
    • PGK‐B
    • cryptorchism
    • sperm isozymes
    • spermatogenesis

    ASJC Scopus subject areas

    • Genetics
    • Developmental Biology
    • Cell Biology

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