Restriction of neurogenic ability during neural crest cell differentiation

Kristine S. Vogel, Michael F. Marusich, James A. Weston

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Multipotent neural crest cells undergo developmental restrictions during embryogenesis and eventually give rise to the neurons and glia of the peripheral nervous system, melanocytes, and pheochromocytes. To understand how neuronal potential is restricted to a subpopulation of crest‐derived cells, we have utilized sensitive markers of early neuronal differentiation to assess neurogenesis in crest‐derived cell populations subjected to defined experimental conditions in vitro and in vivo. We describe environmental conditions that either (a) result in the irreversible loss of neurogenic potential over a characteristic time course or (b) maintain neurogenic potential among neural crest cells. © 1993 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)162-171
Number of pages10
JournalJournal of Neurobiology
Volume24
Issue number2
DOIs
StatePublished - Feb 1993
Externally publishedYes

Keywords

  • developmental restrictions
  • neural crest
  • neurogenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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