Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2- aminopropane

Katherine M. Serafine, Charles P. France

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Feeding conditions can impact sensitivity to drugs acting on dopamine receptors; less is known about the impact of feeding conditions on the effects of drugs acting on serotonin (5-HT) receptors. This study examined the effects of feeding conditions on sensitivity to the direct-acting 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 0.1-3.2 mg/kg) and the direct-acting dopamine D3/D2 receptor agonist quinpirole (0.0032-0.32 mg/kg). Male Sprague-Dawley rats had free access (11 weeks), followed by restricted access (6 weeks), to high fat (34.3%, n=8) or standard (5.7% fat; n=7) chow. Rats eating high fat chow became insulin resistant and gained more weight than rats eating standard chow. Free access to high fat chow did not alter sensitivity to DOM-induced head twitch but increased sensitivity to quinpirole-induced yawning. Restricting access to high fat or standard chow shifted the DOM-induced head twitch dose-response curve to the right and shifted the quinpirole-induced yawning dose-response curve downward in both groups of rats. Some drugs of abuse and many therapeutic drugs act on 5-HT and dopamine systems; these results show that feeding conditions impact sensitivity to drugs acting on these systems, thereby possibly affecting vulnerability to abuse, as well as the therapeutic effectiveness of drugs.

Original languageEnglish (US)
Pages (from-to)44-52
Number of pages9
JournalBehavioural Pharmacology
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2014

    Fingerprint

Keywords

  • 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane
  • dopamine receptor
  • food restriction
  • head twitch
  • high fat food
  • quinpirole
  • rat
  • serotonin receptor
  • yawning

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this