TY - JOUR
T1 - Resting-state causal connectivity of the bed nucleus of the stria terminalis in panic disorder
AU - Pang, Manlong
AU - Zhong, Yuan
AU - Hao, Ziyu
AU - Xu, Huazhen
AU - Wu, Yun
AU - Teng, Changjun
AU - Li, Jian
AU - Xiao, Chaoyong
AU - Fox, Peter T.
AU - Zhang, Ning
AU - Wang, Chun
N1 - Funding Information:
This study was supported by National Natural Science Foundation of China (81571344, 81871344); Natural Science Foundation of Jiangsu Province (BK20161109, BK20191369); the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China (18KJB190003); key research and development program (Social Development) project of Jiangsu province (BE2019609); Nanjing Medical Science and Technique Development Foundation, Outstanding Youth Project (JQX14008).
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - Panic disorder (PD) is associated with anticipatory anxiety, a sustained threat response that appears to be related to the bed nucleus of the stria terminalis (BNST). Individuals with panic disorder may demonstrate significant differences in causal connectivity of the BNST in comparison to healthy controls. To test this hypothesis, resting-state functional magnetic resonance imaging (fMRI) was used to identify aberrant causal connectivity of the BNST in PD patients. 19 PD patients and 18 healthy controls (HC) matched for gender, age and education were included. Granger causality analysis (GCA) utilizing the BNST as a seed region was used to investigate changes in directional connectivity. Relative to healthy controls, PD patients displayed abnormal directional connectivity of the BNST including enhanced causal connectivity between the left parahippocampal gyrus and left BNST, the right insula and the right BNST, the left BNST and the right dorsolateral prefrontal cortex (dlPFC) and right BNST to the left and right dlPFC. Furthermore, PD patients displayed weakened causal connectivity between the right dlPFC and the left BNST, the left dlPFC and the right BNST, the left BNST and the left dorsomedial prefrontal cortex (dmPFC), right insula, right fusiform, and right BNST to the right insula. The results suggest that PD strongly correlates with increased causal connectivity between emotional processing regions and the BNST and enhanced causal connectivity between the BNST and cognitive control regions.
AB - Panic disorder (PD) is associated with anticipatory anxiety, a sustained threat response that appears to be related to the bed nucleus of the stria terminalis (BNST). Individuals with panic disorder may demonstrate significant differences in causal connectivity of the BNST in comparison to healthy controls. To test this hypothesis, resting-state functional magnetic resonance imaging (fMRI) was used to identify aberrant causal connectivity of the BNST in PD patients. 19 PD patients and 18 healthy controls (HC) matched for gender, age and education were included. Granger causality analysis (GCA) utilizing the BNST as a seed region was used to investigate changes in directional connectivity. Relative to healthy controls, PD patients displayed abnormal directional connectivity of the BNST including enhanced causal connectivity between the left parahippocampal gyrus and left BNST, the right insula and the right BNST, the left BNST and the right dorsolateral prefrontal cortex (dlPFC) and right BNST to the left and right dlPFC. Furthermore, PD patients displayed weakened causal connectivity between the right dlPFC and the left BNST, the left dlPFC and the right BNST, the left BNST and the left dorsomedial prefrontal cortex (dmPFC), right insula, right fusiform, and right BNST to the right insula. The results suggest that PD strongly correlates with increased causal connectivity between emotional processing regions and the BNST and enhanced causal connectivity between the BNST and cognitive control regions.
KW - Bed nucleus of the stria terminalis
KW - Granger causality analysis
KW - Panic disorder
KW - Resting-state fMRI
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U2 - 10.1007/s11682-019-00229-x
DO - 10.1007/s11682-019-00229-x
M3 - Article
C2 - 31833015
AN - SCOPUS:85076604836
VL - 15
SP - 25
EP - 35
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 1
ER -