We examined the effects of dietary cholesterol (<0.01 and 1.7 mg/Kcal) and type of fat (saturated, coconut oil; polyunsaturated, corn oil) on very low density plus low density lipoprotein (VLDL+LDL) and high density lipoprotein (HDL) cholesterol in 24 young baboons (12 male, 12 female) (Paplo sp.) in a crossover design experiment. The oils contributed 40% of calories. Total serum cholesterol concentration on the low cholesterol-polyunsaturated fat diet averaged 120 mg/dl; on the high cholesterol-saturated fat diet, 245 mg/dl; and on the other two cholesterol-fat diet combinations, about 200 mg/dl. There was a significant interaction between cholesterol and type of fat in their effects on VLDL + LDL cholesterol, but not in their effects on HDL cholesterol. Dietary cholesterol elevated VLDL + LDL cholesterol when fed with both types of fat, but elevated it more when fed with polyunsaturated fat than with saturated fat. Saturated fat elevated VLDL + LDL cholesterol when dietary cholesterol was low, but not when dietary cholesterol was high. Saturated fat consistently elevated HLD cholesterol more than did dietary cholesterol. The response of apolipoprotein B concentrations to dietary components was similar to that of VLDL + LDL cholesterol. These results indicate that dietary cholesterol and type of fat have different effects on the distribution of cholesterol among the major serum lipoproteins of the baboon.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine