Responses of cultured heart cells to procainamide and lignocaine

David Mccall

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Summary: The effects of procainamide and lignocaine, in concentractions from 10-6 to 10-2mol·litre-1, on the Na influx and contraction frequency of cultured heart cells were studied. Both drugs produced a prompt, dose-dependent reduction in Na influx which was significant (P<0.0l) for all concentrations tested. Lignocaine affected only that portion of the Na influx which was also verapamil-sensitive, whereas procainamide suppressed in addition, the verapamil-insensitive influx. In addition both drugs produced a concomitant decrease in the spontaneous contraction frequency of the cells. A close linear correlation (r - 0.99) between verapamil-sensitive Na influx and contraction frequency, in the presence of both procainamide and lignocaine was found. From this, and previous studies indicating a dependency of contraction frequency on the inward verapamil-sensitive Na influx, it is suggested that the drugs modify the automaticity of this preparation by a primary influence on membrane Na exchange.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalCardiovascular Research
Volume12
Issue number9
DOIs
StatePublished - Sep 1978

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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