TY - JOUR
T1 - Responses of cultured heart cells to procainamide and lignocaine
AU - Mccall, David
N1 - Funding Information:
Supported in part by a grant from the Southwestern Ohio Chapter of the American Heart Association.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1978/9
Y1 - 1978/9
N2 - Summary: The effects of procainamide and lignocaine, in concentractions from 10-6 to 10-2mol·litre-1, on the Na influx and contraction frequency of cultured heart cells were studied. Both drugs produced a prompt, dose-dependent reduction in Na influx which was significant (P<0.0l) for all concentrations tested. Lignocaine affected only that portion of the Na influx which was also verapamil-sensitive, whereas procainamide suppressed in addition, the verapamil-insensitive influx. In addition both drugs produced a concomitant decrease in the spontaneous contraction frequency of the cells. A close linear correlation (r - 0.99) between verapamil-sensitive Na influx and contraction frequency, in the presence of both procainamide and lignocaine was found. From this, and previous studies indicating a dependency of contraction frequency on the inward verapamil-sensitive Na influx, it is suggested that the drugs modify the automaticity of this preparation by a primary influence on membrane Na exchange.
AB - Summary: The effects of procainamide and lignocaine, in concentractions from 10-6 to 10-2mol·litre-1, on the Na influx and contraction frequency of cultured heart cells were studied. Both drugs produced a prompt, dose-dependent reduction in Na influx which was significant (P<0.0l) for all concentrations tested. Lignocaine affected only that portion of the Na influx which was also verapamil-sensitive, whereas procainamide suppressed in addition, the verapamil-insensitive influx. In addition both drugs produced a concomitant decrease in the spontaneous contraction frequency of the cells. A close linear correlation (r - 0.99) between verapamil-sensitive Na influx and contraction frequency, in the presence of both procainamide and lignocaine was found. From this, and previous studies indicating a dependency of contraction frequency on the inward verapamil-sensitive Na influx, it is suggested that the drugs modify the automaticity of this preparation by a primary influence on membrane Na exchange.
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U2 - 10.1093/cvr/12.9.529
DO - 10.1093/cvr/12.9.529
M3 - Review article
C2 - 737666
AN - SCOPUS:0018241935
VL - 12
SP - 529
EP - 536
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 9
ER -