Response of focal refractory status epilepticus to lacosamide in an infant

Asra Akbar, Aaron A. Harthan, Sean Creeden, Girish G. Deshpande

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Status epilepticus (SE) is a life-threatening medical emergency which is frequently encountered in the critical care setting and can be refractory to treatment. Refractory status epilepticus (RSE) is defined as SE that has failed to respond to adequately used first-line and second-line antiepileptic medications. Super refractory status epilepticus is defined as SE that persists for 24 hours or more after the use of an anaesthetic agent or recurs after its withdrawal. If SE persists beyond a period of 7 days it is referred to as prolonged, refractory status epilepticus (PRSE). There are limited data guiding treatment of RSE in the paediatric population. Lacosamide (LCM) is licensed as an adjunctive treatment for partial-onset seizures. Evidence for the efficacy of LCM in paediatric SE is scarce. This case report may suggest a synergistic effect of LCM on slow-activation sodium channels in conjunction with medications such as phenytoin that causes fast inactivation of sodium channels. The dual fast and slow inactivation of sodium channels may enhance the effectiveness in treatment of RSE. This is the first case report of PRSE in an infant, successfully treated with LCM. A brief review of literature is also a part of this report.

Original languageEnglish (US)
Article numbere249948
JournalBMJ case reports
Issue number4
StatePublished - Apr 29 2022
Externally publishedYes


  • Drugs: CNS (not psychiatric)
  • Epilepsy and seizures
  • Neonatal and paediatric intensive care
  • Neurology
  • Paediatric intensive care

ASJC Scopus subject areas

  • General Medicine


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