Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy

V. A. Passero; B. F. Branstetter; Y. Shuai; D. E. Heron; M. K. Gibson; S. Y. Lai; S. W. Kim; J. R. Grandis; R. L. Ferris; J. T. Johnson; A. Argiris

doi:10.1093/annonc/mdq226

Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy

V. A. Passero, B. F. Branstetter, Y. Shuai, D. E. Heron, M. K. Gibson, S. Y. Lai, S. W. Kim, J. R. Grandis, R. L. Ferris, J. T. Johnson, A. Argiris

Mays Cancer Center

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Purpose: RECIST have limitations when applied to potentially curable locally advanced squamous cell carcinoma of the head and neck (SCCHN). [¹⁸F]fluorodeoxyglucose-positron emission tomography (PET) scan may be useful in assessing treatment response and predicting patient outcome. Patients and methods: We studied patients with previously untreated stages III-IVb SCCHN treated with primary concurrent chemoradiotherapy on five prospective clinical trials. Response was assessed by clinical exam, computed tomography (CT), and PET portions of combined PET-CT scan ∼8 weeks after completion of chemoradiotherapy.Results: Fifty-three patients were analyzed. Complete response (CR) was demonstrated in 42 patients (79%) by clinical exam, 15 (28%) by CT, and 27 (51%) by PET. CR as assessed by PET, but not as assessed by clinical exam or CT using RECIST, correlated significantly with progression-free status (PFS) (P < 0.0001). The 2-year PFS for patients with CR and without CR by PET was 93% and 48%, respectively (P = 0.0002).Conclusions: A negative PET scan on combined PET-CT after chemoradiotherapy is a powerful predictor of outcome in patients receiving curative chemoradiotherapy for SCCHN. PET-CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT.

Original language	English (US)
Pages (from-to)	2278-2283
Number of pages	6
Journal	Annals of Oncology
Volume	21
Issue number	11
DOIs	https://doi.org/10.1093/annonc/mdq226
State	Published - Nov 2010

Keywords

Chemoradiotherapy
Head and neck cancer
Objective response
PET-CT
RECIST

ASJC Scopus subject areas

Hematology
Oncology

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Passero, V. A., Branstetter, B. F., Shuai, Y., Heron, D. E., Gibson, M. K., Lai, S. Y., Kim, S. W., Grandis, J. R., Ferris, R. L., Johnson, J. T., & Argiris, A. (2010). Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy. Annals of Oncology, 21(11), 2278-2283. https://doi.org/10.1093/annonc/mdq226

Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy. / Passero, V. A.; Branstetter, B. F.; Shuai, Y.; Heron, D. E.; Gibson, M. K.; Lai, S. Y.; Kim, S. W.; Grandis, J. R.; Ferris, R. L.; Johnson, J. T.; Argiris, A.

In: Annals of Oncology, Vol. 21, No. 11, 11.2010, p. 2278-2283.

Research output: Contribution to journal › Article › peer-review

Passero, VA, Branstetter, BF, Shuai, Y, Heron, DE, Gibson, MK, Lai, SY, Kim, SW, Grandis, JR, Ferris, RL, Johnson, JT & Argiris, A 2010, 'Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy', Annals of Oncology, vol. 21, no. 11, pp. 2278-2283. https://doi.org/10.1093/annonc/mdq226

Passero, V. A. ; Branstetter, B. F. ; Shuai, Y. ; Heron, D. E. ; Gibson, M. K. ; Lai, S. Y. ; Kim, S. W. ; Grandis, J. R. ; Ferris, R. L. ; Johnson, J. T. ; Argiris, A. / Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy. In: Annals of Oncology. 2010 ; Vol. 21, No. 11. pp. 2278-2283.

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abstract = "Purpose: RECIST have limitations when applied to potentially curable locally advanced squamous cell carcinoma of the head and neck (SCCHN). [18F]fluorodeoxyglucose-positron emission tomography (PET) scan may be useful in assessing treatment response and predicting patient outcome. Patients and methods: We studied patients with previously untreated stages III-IVb SCCHN treated with primary concurrent chemoradiotherapy on five prospective clinical trials. Response was assessed by clinical exam, computed tomography (CT), and PET portions of combined PET-CT scan ∼8 weeks after completion of chemoradiotherapy.Results: Fifty-three patients were analyzed. Complete response (CR) was demonstrated in 42 patients (79%) by clinical exam, 15 (28%) by CT, and 27 (51%) by PET. CR as assessed by PET, but not as assessed by clinical exam or CT using RECIST, correlated significantly with progression-free status (PFS) (P < 0.0001). The 2-year PFS for patients with CR and without CR by PET was 93% and 48%, respectively (P = 0.0002).Conclusions: A negative PET scan on combined PET-CT after chemoradiotherapy is a powerful predictor of outcome in patients receiving curative chemoradiotherapy for SCCHN. PET-CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT.",

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author = "Passero, {V. A.} and Branstetter, {B. F.} and Y. Shuai and Heron, {D. E.} and Gibson, {M. K.} and Lai, {S. Y.} and Kim, {S. W.} and Grandis, {J. R.} and Ferris, {R. L.} and Johnson, {J. T.} and A. Argiris",

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AU - Passero, V. A.

AU - Branstetter, B. F.

AU - Shuai, Y.

AU - Heron, D. E.

AU - Gibson, M. K.

AU - Lai, S. Y.

AU - Kim, S. W.

AU - Grandis, J. R.

AU - Ferris, R. L.

AU - Johnson, J. T.

AU - Argiris, A.

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N2 - Purpose: RECIST have limitations when applied to potentially curable locally advanced squamous cell carcinoma of the head and neck (SCCHN). [18F]fluorodeoxyglucose-positron emission tomography (PET) scan may be useful in assessing treatment response and predicting patient outcome. Patients and methods: We studied patients with previously untreated stages III-IVb SCCHN treated with primary concurrent chemoradiotherapy on five prospective clinical trials. Response was assessed by clinical exam, computed tomography (CT), and PET portions of combined PET-CT scan ∼8 weeks after completion of chemoradiotherapy.Results: Fifty-three patients were analyzed. Complete response (CR) was demonstrated in 42 patients (79%) by clinical exam, 15 (28%) by CT, and 27 (51%) by PET. CR as assessed by PET, but not as assessed by clinical exam or CT using RECIST, correlated significantly with progression-free status (PFS) (P < 0.0001). The 2-year PFS for patients with CR and without CR by PET was 93% and 48%, respectively (P = 0.0002).Conclusions: A negative PET scan on combined PET-CT after chemoradiotherapy is a powerful predictor of outcome in patients receiving curative chemoradiotherapy for SCCHN. PET-CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT.

AB - Purpose: RECIST have limitations when applied to potentially curable locally advanced squamous cell carcinoma of the head and neck (SCCHN). [18F]fluorodeoxyglucose-positron emission tomography (PET) scan may be useful in assessing treatment response and predicting patient outcome. Patients and methods: We studied patients with previously untreated stages III-IVb SCCHN treated with primary concurrent chemoradiotherapy on five prospective clinical trials. Response was assessed by clinical exam, computed tomography (CT), and PET portions of combined PET-CT scan ∼8 weeks after completion of chemoradiotherapy.Results: Fifty-three patients were analyzed. Complete response (CR) was demonstrated in 42 patients (79%) by clinical exam, 15 (28%) by CT, and 27 (51%) by PET. CR as assessed by PET, but not as assessed by clinical exam or CT using RECIST, correlated significantly with progression-free status (PFS) (P < 0.0001). The 2-year PFS for patients with CR and without CR by PET was 93% and 48%, respectively (P = 0.0002).Conclusions: A negative PET scan on combined PET-CT after chemoradiotherapy is a powerful predictor of outcome in patients receiving curative chemoradiotherapy for SCCHN. PET-CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT.

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