Respiratory supercomplexes: Structure, function and assembly

Rasika Vartak, Christina Ann Marie Porras, Yidong Bai

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

The mitochondrial respiratory chain consists of 5 enzyme complexes that are responsible for ATP generation. The paradigm of the electron transport chain as discrete enzymes diffused in the inner mitochondrial membrane has been replaced by the solid state supercomplex model wherein the respiratory complexes associate with each other to form supramolecular complexes. Defects in these supercomplexes, which have been shown to be functionally active and required for forming stable respiratory complexes, have been associated with many genetic and neurodegenerative disorders demonstrating their biomedical significance. In this review, we will summarize the functional and structural significance of supercomplexes and provide a comprehensive review of their assembly and the assembly factors currently known to play a role in this process.

Original languageEnglish (US)
Pages (from-to)582-590
Number of pages9
JournalProtein and Cell
Volume4
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • mitochondrial
  • respiration
  • supercomplex

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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