Abstract
The plasticity model of the electron transport chain has slowly begun to replace both the liquid model of free complexes and the solid model of supercomplexes. The plasticity model predicts that respiratory complexes exist and function both as single complexes and as supercomplexes. The advantages of this system is an electron transport train which is able to adapt to changes in its environment. This review will investigate the current body of work on supercomplexes including their assembly, regulation, and plasticity, and particularly their role in the generation of reactive oxygen species and aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 621-634 |
| Number of pages | 14 |
| Journal | Frontiers in Bioscience - Landmark |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 15 2015 |
Keywords
- Mitochondria
- ROS
- Respiration
- Review
- Supercomplex
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)