Abstract
Reactive oxygen and nitrogen species are generated by several inflammatory and structural cells of the airways. These oxidant species have important effects on a variety of lung cells as regulators of signal transduction, activators of key transcription factors and modulators of gene expression and apoptosis. Thus, increased oxidative stress accompanied by reduced endogenous antioxidant defenses may play a role in the pathogenesis of a number of inflammatory pulmonary diseases, including respiratory distress syndrome (RDS) in the newborn. There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS. Clearly, utilizing lung protective strategies requires compromises between gas exchange goals and potential toxicities associated with over-distension, derecruitment of lung units and high oxygen concentrations. The results discussed in this brief review suggest rigorous clinical tests with antioxidants which may help to define the mechanisms associated with RDS and which could lead to new treatment strategies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1116-1123 |
| Number of pages | 8 |
| Journal | Intensive Care Medicine, Supplement |
| Volume | 27 |
| Issue number | 1 |
| State | Published - 2001 |
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Keywords
- Antioxidants
- Distress respiratory syndrome
- Oxidative stress
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Respiratory distress syndrome in the newborn : Role of oxidative stress. / Gitto, E.; Reiter, Russel J; Karbownik, M.; Xian-Tan, D.; Barberi, I.
In: Intensive Care Medicine, Supplement, Vol. 27, No. 1, 2001, p. 1116-1123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Respiratory distress syndrome in the newborn
T2 - Role of oxidative stress
AU - Gitto, E.
AU - Reiter, Russel J
AU - Karbownik, M.
AU - Xian-Tan, D.
AU - Barberi, I.
PY - 2001
Y1 - 2001
N2 - Reactive oxygen and nitrogen species are generated by several inflammatory and structural cells of the airways. These oxidant species have important effects on a variety of lung cells as regulators of signal transduction, activators of key transcription factors and modulators of gene expression and apoptosis. Thus, increased oxidative stress accompanied by reduced endogenous antioxidant defenses may play a role in the pathogenesis of a number of inflammatory pulmonary diseases, including respiratory distress syndrome (RDS) in the newborn. There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS. Clearly, utilizing lung protective strategies requires compromises between gas exchange goals and potential toxicities associated with over-distension, derecruitment of lung units and high oxygen concentrations. The results discussed in this brief review suggest rigorous clinical tests with antioxidants which may help to define the mechanisms associated with RDS and which could lead to new treatment strategies.
AB - Reactive oxygen and nitrogen species are generated by several inflammatory and structural cells of the airways. These oxidant species have important effects on a variety of lung cells as regulators of signal transduction, activators of key transcription factors and modulators of gene expression and apoptosis. Thus, increased oxidative stress accompanied by reduced endogenous antioxidant defenses may play a role in the pathogenesis of a number of inflammatory pulmonary diseases, including respiratory distress syndrome (RDS) in the newborn. There obviously are conflicting reports on the effect of oxygen, ventilation and nitric oxide (NO) on RDS and, thus, the question arises as what the neonatologist should do when confronted with a newborn with RDS. Clearly, utilizing lung protective strategies requires compromises between gas exchange goals and potential toxicities associated with over-distension, derecruitment of lung units and high oxygen concentrations. The results discussed in this brief review suggest rigorous clinical tests with antioxidants which may help to define the mechanisms associated with RDS and which could lead to new treatment strategies.
KW - Antioxidants
KW - Distress respiratory syndrome
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0034901390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034901390&partnerID=8YFLogxK
M3 - Article
VL - 27
SP - 1116
EP - 1123
JO - Intensive Care Medicine, Supplement
JF - Intensive Care Medicine, Supplement
SN - 0935-1701
IS - 1
ER -