Resolving inflammatory links between myocardial infarction and vascular dementia

Edward B. Thorp, Margaret E. Flanagan, Brian Popko, Matthew DeBerge

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Myocardial infarction is associated with increased risk for vascular dementia. In both myocardial infarction and vascular dementia, there is evidence that elevated inflammatory biomarkers are associated with worsened clinical outcomes. Myocardial infarction leads to a systemic inflammatory response, which may contribute to recruitment or activation of myeloid cells, including monocytes, microglia, and perivascular macrophages, within the central nervous system. However, our understanding of the causative roles for these cells linking cardiac injury to the development and progression of dementia is incomplete. Herein, we provide an overview of inflammatory cellular and molecular links between myocardial infarction and vascular dementia and discuss strategies to resolve inflammation after myocardial infarction to limit neurovascular injury.

Original languageEnglish (US)
Article number101600
JournalSeminars in Immunology
Volume59
DOIs
StatePublished - Jan 2022
Externally publishedYes

Keywords

  • Myocardial infarction
  • Vascular dementia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Resolving inflammatory links between myocardial infarction and vascular dementia'. Together they form a unique fingerprint.

Cite this