Resistin: Functional roles and therapeutic considerations for cardiovascular disease

Md S. Jamaluddin, Sarah M. Weakley, Qizhi Yao, Changyi Chen

Research output: Contribution to journalReview article

199 Scopus citations

Abstract

Resistin, originally described as an adipocyte-specific hormone, has been suggested to be an important link between obesity, insulin resistance and diabetes. Although its expression was initially defined in adipocytes, significant levels of resistin expression in humans are mainly found in mononuclear leukocytes, macrophages, spleen and bone marrow cells. Increasing evidence indicates that resistin plays important regulatory roles apart from its role in insulin resistance and diabetes in a variety of biological processes: atherosclerosis and cardiovascular disease (CVD), non-alcoholic fatty liver disease, autoimmune disease, malignancy, asthma, inflammatory bowel disease and chronic kidney disease. As CVD accounts for a significant amount of morbidity and mortality in patients with diabetes and without diabetes, it is important to understand the role that adipokines such as resistin play in the cardiovascular system. Evidence suggests that resistin is involved in pathological processes leading to CVD including inflammation, endothelial dysfunction, thrombosis, angiogenesis and smooth muscle cell dysfunction. The modes of action and signalling pathways whereby resistin interacts with its target cells are beginning to be understood. In this review, the current knowledge about the functions and pathophysiological implications of resistin in CVD development is summarized; clinical translations, therapeutic considerations and future directions in the field of resistin research are discussed. Linked Articles This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit

Original languageEnglish (US)
Pages (from-to)622-632
Number of pages11
JournalBritish Journal of Pharmacology
Volume165
Issue number3
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Keywords

  • angiogenesis
  • atherosclerosis
  • cardiovascular disease
  • endothelial dysfunction
  • human peripheral blood monocytes
  • inflammation
  • resistin
  • thrombosis

ASJC Scopus subject areas

  • Pharmacology

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