Resistance to rapamycin: A novel anticancer drug

Shile Huang; Peter J. Houghton

doi:10.1023/A:1013167315885

Resistance to rapamycin: A novel anticancer drug

Shile Huang, Peter J. Houghton

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The macrocyclic lactone rapamycin has an established place as an immune suppressive agent in organ transplantation. However, more recently it has been recognized as an inhibitor of pathways that may be activated during malignant transformation and tumor progression. Thus, increasing interest is being directed to this class of antibiotic as potential antitumor agents. Here we summarize the history, mechanism of action, and mechanisms of resistance to rapamycin.

Original language	English (US)
Pages (from-to)	69-78
Number of pages	10
Journal	Cancer and Metastasis Reviews
Volume	20
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1013167315885
State	Published - Dec 1 2001
Externally published	Yes

Keywords

Apoptosis
Cancer
Cell cycle
Cell proliferation
Rapamycin
Resistance

ASJC Scopus subject areas

Oncology
Cancer Research

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AB - The macrocyclic lactone rapamycin has an established place as an immune suppressive agent in organ transplantation. However, more recently it has been recognized as an inhibitor of pathways that may be activated during malignant transformation and tumor progression. Thus, increasing interest is being directed to this class of antibiotic as potential antitumor agents. Here we summarize the history, mechanism of action, and mechanisms of resistance to rapamycin.

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KW - Cell cycle

KW - Cell proliferation

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KW - Resistance

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