Resistance to insulin-induced hyperphagia in fat-preferring rats

A. Prasad, M. Happel, C. Prasad

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Outbred male Sprague-Dawley rats were screened for their macronutrient (fat, carbohydrate and protein) preference profile and divided into two groups, the low- and high fat-preferring groups each deriving 23% and 72% of its total caloric intake from fat respectively. Subcutaneous administration of bovine insulin (6U/kg) resulted in an increase in total caloric intake in the low, but not the high fat-preferring group. Furthermore, the increased caloric intake in the low fat-preferring group was entirely due to increased carbohydrate consumption. These data suggest a defect in the action of insulin in fat-preferring rats.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
Issue number3
StatePublished - Nov 1992
Externally publishedYes

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Neurology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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