Resistance of candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with aids: Documentation by in vitro susceptibility testing and dna subtype analysis

S. Redding, J. Smith, G. Farinacci, M. Rinaldi, A. Fothergill, J. Rhine-Chalberg, M. Pfaller

Research output: Contribution to journalArticlepeer-review

240 Scopus citations

Abstract

We describe a patient with recurrent episodes of oropharyngeal candidiasis who required progressively higher doses of fluconazole to control the infection. The patient was treated for 14 infections over a 2-year period with doses of fluconazole that ranged from 100 to 800 mg per day. Clinical response, two methods of in vitro susceptibility testing, and molecular epidemiologic techniques were evaluated for 12 of the 14 episodes. Ultimately, the patient became unresponsive clinically to a dose of 800 mg of fluconazole per day. In vitro susceptibility testing of isolates obtained during these successive episodes of infection revealed the development of resistance to fluconazole, and molecular epidemiologic techniques confirmed the persistence of the same Candida albicans strain throughout all 12 episodes.

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
JournalClinical Infectious Diseases
Volume18
Issue number2
DOIs
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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