Resection of isolated distant nodal metastasis in metastatic colorectal cancer

Chelsea Isom, Kamran Idrees, Li Wang, Marcus Tan, Alexander A. Parikh, Christina E. Bailey

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Little is known regarding the role of resection in patients with colorectal cancer (CRC) who present with isolated non-regional lymph node metastasis (NRLNM). Methods: Using the Surveillance, Epidemiology and End Results database, we identified patients diagnosed with CRC and NRLNM from 2004 to 2013. Results: A total of 849 patients presented with CRC and isolated NRLNM. Of these, 90 (10.6%) underwent resection of NRLNM. Median overall survival (OS) did not differ for patients who underwent resection of NRLNM compared to those who did not (33 versus 29 months, p = 0.68). Subgroup analysis by primary tumor site, also did not demonstrate a difference in median OS. Cox proportional hazard model revealed older age (Hazard ratio [HR] 1.34, 95% Confidence Interval [CI] 1.17–1.53, p < 0.0001), higher tumor grade (HR 1.81, 95% CI 1.52–2.16, p < 0.0001), and earlier year of diagnosis (HR 1.34, 95% CI 1.17–1.53, p < 0.0001) were associated with decreased OS. There was no survival difference between those who underwent resection of NRLNM compared to those who had not (HR 0.997, p = 0.28). Conclusion: Resection of NRLNM in patients with CRC is not associated with an OS benefit. Further studies are needed to determine if there is a subset of patients who could potentially benefit from this resection strategy.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalSurgical Oncology
Volume33
DOIs
StatePublished - Jun 2020
Externally publishedYes

Keywords

  • Colorectal cancer
  • Nodal metastasis
  • Nodal resection

ASJC Scopus subject areas

  • Oncology
  • Surgery

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