Research advances in the mutation of TET2 gene in myeloid maligancies

Rong Li; Ming Jiang Xu; Feng Chun Yang; Yuan Zhou

doi:10.3881/j.issn.1000-503X.2016.05.017

Research advances in the mutation of TET2 gene in myeloid maligancies

Rong Li, Ming Jiang Xu, Feng Chun Yang, Yuan Zhou

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review, the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

Original language	English (US)
Pages (from-to)	583-588
Number of pages	6
Journal	Acta Academiae Medicinae Sinicae
Volume	38
Issue number	5
DOIs	https://doi.org/10.3881/j.issn.1000-503X.2016.05.017
State	Published - Oct 30 2016
Externally published	Yes

Keywords

Mutation
Myeloid malignancies
TET2

ASJC Scopus subject areas

General Medicine

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10.3881/j.issn.1000-503X.2016.05.017

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title = "Research advances in the mutation of TET2 gene in myeloid maligancies",

abstract = "TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review, the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.",

keywords = "Mutation, Myeloid malignancies, TET2",

author = "Rong Li and Xu, {Ming Jiang} and Yang, {Feng Chun} and Yuan Zhou",

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T1 - Research advances in the mutation of TET2 gene in myeloid maligancies

AU - Li, Rong

AU - Xu, Ming Jiang

AU - Yang, Feng Chun

AU - Zhou, Yuan

PY - 2016/10/30

Y1 - 2016/10/30

N2 - TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review, the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

AB - TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review, the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

KW - Mutation

KW - Myeloid malignancies

KW - TET2

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DO - 10.3881/j.issn.1000-503X.2016.05.017

M3 - Review article

C2 - 27825418

AN - SCOPUS:85008888948

SN - 1000-503X

VL - 38

SP - 583

EP - 588

JO - Acta Academiae Medicinae Sinicae

JF - Acta Academiae Medicinae Sinicae

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ER -

Research advances in the mutation of TET2 gene in myeloid maligancies

Abstract

Keywords

ASJC Scopus subject areas

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