TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review, the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.
|Original language||English (US)|
|Number of pages||6|
|Journal||Acta Academiae Medicinae Sinicae|
|State||Published - Oct 30 2016|
- Myeloid malignancies
ASJC Scopus subject areas