Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Nathan P. Wiederhold; Thomas F. Patterson; Anand Srinivasan; Ashok K. Chaturvedi; Annette W. Fothergill; Floyd L. Wormley; Anand K. Ramasubramanian; José L. Lopez-Ribot

doi:10.1080/21505594.2016.1196301

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Nathan P. Wiederhold
, Thomas F. Patterson
, Anand Srinivasan
, Ashok K. Chaturvedi
, Annette W. Fothergill
, Floyd L. Wormley
, Anand K. Ramasubramanian
, José L. Lopez-Ribot

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.

Original language	English (US)
Pages (from-to)	138-142
Number of pages	5
Journal	Virulence
Volume	8
Issue number	2
DOIs	https://doi.org/10.1080/21505594.2016.1196301
State	Published - Feb 17 2017

Keywords

antifungal susceptibility
auranofin
repurposing
spectrum of action

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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10.1080/21505594.2016.1196301

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abstract = "Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.",

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AU - Srinivasan, Anand

AU - Chaturvedi, Ashok K.

AU - Fothergill, Annette W.

AU - Wormley, Floyd L.

AU - Ramasubramanian, Anand K.

AU - Lopez-Ribot, José L.

PY - 2017/2/17

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KW - auranofin

KW - repurposing

KW - spectrum of action

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Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Abstract

Keywords

ASJC Scopus subject areas

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