Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Nathan P. Wiederhold, Thomas F. Patterson, Anand Srinivasan, Ashok K. Chaturvedi, Annette W. Fothergill, Floyd L. Wormley, Anand K. Ramasubramanian, José L. Lopez-Ribot

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalVirulence
Volume8
Issue number2
DOIs
StatePublished - Feb 17 2017

Keywords

  • antifungal susceptibility
  • auranofin
  • repurposing
  • spectrum of action

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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