Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Nathan Wiederhold; Thomas F Patterson; Anand Srinivasan; Ashok K. Chaturvedi; Annette W. Fothergill; Floyd L. Wormley; Anand K. Ramasubramanian; José L. Lopez-Ribot

doi:10.1080/21505594.2016.1196301

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Nathan Wiederhold, Thomas F Patterson, Anand Srinivasan, Ashok K. Chaturvedi, Annette W. Fothergill, Floyd L. Wormley, Anand K. Ramasubramanian, José L. Lopez-Ribot

Research output: Contribution to journal › Article

23 Scopus citations

Abstract

Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Virulence
DOIs	https://doi.org/10.1080/21505594.2016.1196301
State	Accepted/In press - Jun 24 2016

Keywords

antifungal susceptibility
auranofin
repurposing
spectrum of action

ASJC Scopus subject areas

Infectious Diseases
Microbiology
Parasitology
Immunology
Microbiology (medical)

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10.1080/21505594.2016.1196301

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Wiederhold, N., Patterson, T. F., Srinivasan, A., Chaturvedi, A. K., Fothergill, A. W., Wormley, F. L., Ramasubramanian, A. K., & Lopez-Ribot, J. L. (Accepted/In press). Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi. Virulence, 1-5. https://doi.org/10.1080/21505594.2016.1196301

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