TY - JOUR
T1 - Repurposing auranofin as an antifungal
T2 - In vitro activity against a variety of medically important fungi
AU - Wiederhold, Nathan P.
AU - Patterson, Thomas F.
AU - Srinivasan, Anand
AU - Chaturvedi, Ashok K.
AU - Fothergill, Annette W.
AU - Wormley, Floyd L.
AU - Ramasubramanian, Anand K.
AU - Lopez-Ribot, José L.
N1 - Funding Information:
This project utilized preclinical services funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract Nos. HHS272201000018I, Task Order A06. Additional support was provided by the Army Research Office of the Department of Defense under Contract No. W911NF-11-1-0136, by a Clusters in Research Excellence grant from the San Antonio Life Science Institute (SALSI) and by the Margaret Batts Tobin Foundation, San Antonio, TX. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, and the content is solely the responsibility of the authors.
Publisher Copyright:
© 2017 Taylor & Francis.
PY - 2017/2/17
Y1 - 2017/2/17
N2 - Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.
AB - Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.
KW - antifungal susceptibility
KW - auranofin
KW - repurposing
KW - spectrum of action
UR - http://www.scopus.com/inward/record.url?scp=84976291300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976291300&partnerID=8YFLogxK
U2 - 10.1080/21505594.2016.1196301
DO - 10.1080/21505594.2016.1196301
M3 - Article
C2 - 27268469
AN - SCOPUS:84976291300
VL - 8
SP - 138
EP - 142
JO - Virulence
JF - Virulence
SN - 2150-5594
IS - 2
ER -