Reproductive deficiency of NZB male mice. Possibility of a viral basis

G. Fernandes, E. J. Yunis, E. J. Yunis, R. A. Good

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Breeding efficiency and litter size of NZB mice are compared to those of several other autoimmunity susceptible and autoimmunity resistant inbred strains. It was seen that NZB mice have a limited period of breeding capacity, whereas other strains produce litters for a greater time. Observations were also made on litter size in relation to litter rank. It was seen that NZB mice show progressive reduction in litter size, whereas in autoimmunity resistant strains, litters enlarge at first and decline only as the animals age. Litter size in all combinations studied could be attributed to an influence exerted through the NZB males. The presence of viral particles in the reproductive organs of NZB males suggests a relation between the presence of the virus and the reproductive deficiencies of the NZB males. The observations suggest that extensive immunobiologic studies on NZB animals should be carried out to determine whether autoimmunity against sperm or ejaculatory components develops early in life in NZB males. Further studies on virus load and of endocrine characteristics of NZB mice are needed to dissect this provocative observation.

Original languageEnglish (US)
Pages (from-to)278-281
Number of pages4
JournalLaboratory Investigation
Volume29
Issue number3
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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