Reproducibility of the French‐American‐British classification of acute Leukemia: The southwest oncology group experience

David R. Head, Richard A. Savage, Lizardo Cerezo, Catherine M. Craven, John N. Bickers, Robert Hartsock, Thomas A. Hosty, John H. Saiki, Henry E. Wilson, Francis S. Morrison, Charles A. Coltman, John J. Hutton

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

After initial French‐American‐British (FAB) diagnosis by a multiinstitutional Southwest Oncology Group panel, slides of acute leukemia cases were recirculated to panel members for second review. The reproducibility of the FAB classification is analyzed. The classification is reproducible in the 70% range in panel reviewer hands and allows remarkable reproducibility in the morphologic and cytochemical distinction of acute lymphoid leukemia (ALL) from acute myeloid leukemia (AML). The limitations of a morphologic and cytochemical classification of acute leukemia are discussed. A simplification of the FAB system, merging M1, M2, and M4 as M7, is proposed; this simplification improves the system's reproducibility.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalAmerican Journal of Hematology
Volume18
Issue number1
DOIs
StatePublished - Jan 1985
Externally publishedYes

Keywords

  • acute leukemia
  • FAB

ASJC Scopus subject areas

  • Hematology

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