Reproducibility of disc susceptibility tests with haemophilus influenzae

A. L. Barry, J. H. Jorgensen, D. J. Hardy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Triplicate susceptibility tests were performed in each of three laboratories with 45 strains of Haemophilus influenzae and a single lot of Haemophilus test medium (HTM) agar plates. Using clarithromycin, erythromycin and chloramphenicol discs, zone sizes varied over ranges averaging only 4.3-5.8 mm. Ampicillin zone sizes were more variable, especially when β-lactamase-producing strains were being tested, but the latter strains were consistently categorized as being resistant. A 94% interpretive consistency was observed with the two macrolides.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Issue number3
StatePublished - Mar 1991

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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