Repression by sustained-release ß-glucuronidase inhibitors of chemical carcinogen-mediated induction of a marker oncofetal protein in rodents

Z. Walaszek, M. Hanausek-Walaszek, Webb

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The degree of induction of an oncofetal protein marker in rodents by selected chemical carcinogens has been correlated with changes in carcinogenicity induced by dietary D-glucaro-1, 4-lactone (GL) based anticarcinogens. These potent anticarcinogens may act to increase the clearance of carcinogens as glucuronides through the inhibition of ß-glucuronidase. The sustained-release forms are particularly effective, 7.5 mmol/kg of GL maintaining serum ß-glucuronidase activity at or below 50% for only 1 h, while an equivalent amount of calcium glucarate (CCT) maintained this level of inhibition for over 5 h. CCT or other sustained-release inhibitors, when fed to rodents during administration of carcinogens that undergo glucuronidation, caused a marked reduction in the induction of the marker protein. For those systems where other markers of carcinogenesis were also assessed, it was determined that the inhibition of marker-protein induction was quantitatively similar to both the inhibition of binding of the carcinogen o DNA and the subsequent induction of tumors in target organs.

Original languageEnglish (US)
Pages (from-to)15-27
Number of pages13
JournalJournal of toxicology and environmental health
Volume23
Issue number1
DOIs
StatePublished - Jan 1988
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pollution

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