Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians

V. Saroja Voruganti, Nora Franceschini, Karin Haack, Sandra Laston, Jean W. MacCluer, Jason G. Umans, Anthony G. Comuzzie, Kari E. North, Shelley A. Cole

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Increased serum uric acid (SUA) or hyperuricemia, a risk factor for gout, renal and cardiovascular diseases, is caused by either increased production or decreased excretion of uric acid or a mix of both. The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes a transporter that mediates urate flux across the renal proximal tubule. Genome-wide association studies have consistently shown the association of single-nucleotide polymorphisms in this gene with SUA in majority populations. American Indian participants of the Strong Heart Family Study, belonging to multigenerational families, have high prevalence of hyperuricemia. We conducted measured genotype analyses, based on variance components decomposition method and accounting for family relationships, to assess whether the association between SUA and SLC2A9 gene polymorphisms generalized to American Indians (n=3604) of this study. Seven polymorphisms were selected for genotyping based on their association with SUA levels in other populations. A strong association was found between SLC2A9 gene polymorphisms and SUA in all centers combined (P-values: 1.3 × 10 -31 -5.1 × 10 -23) and also when stratified by recruitment center; P-values: 1.2 × 10 -14 -1.0 × 10 -5. These polymorphisms were also associated with the estimated glomerular filtration rate and serum creatinine but not albumin-creatinine ratio. In summary, the association of polymorphisms in the uric acid transporter gene with SUA levels extends to a new population of American Indians.

Original languageEnglish (US)
Pages (from-to)938-943
Number of pages6
JournalEuropean Journal of Human Genetics
Volume22
Issue number7
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • Genetic variation
  • Single-nucleotide polymorphisms
  • Uric acid

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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