Reperfused-viable and reperfused-infarcted myocardium: Differentiation with in vivo P-31 MR spectroscopy

R. B. Rehr, J. L. Tatum, J. I. Hirsch, R. Quint, Geoffrey D Clarke

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The ability of in vivo phosphorus-31 magnetic resonance (MR) spectroscopy to permit accurate distinction between reperfused-viable and reperfused-infarcted myocardium was examined in a canine model of acute coronary occlusion. In vivo myocardial pH and phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were measured at baseline and for the first 90 minutes after reperfusion of a total coronary artery occlusion producing either predominantly viable (nine animals) or infarcted (nine animals) myocardium in the region of metabolic study. Myocardial viability was assessed in each animal by means of postmortem triphenyltetrazolium chloride staining. Tissue was characterized from the in vivo P-31 MR data by means of logistic regression analysis. The accuracy of using the P-31 MR data for distinguishing reperfused-viable from reperfused-infarcted myocardium was 100% (69 of 69 data points, 18 of 18 animals). Results of the logistic regression procedure indicated that phosphocreatine was the metabolic variable enabling most effective separation of reperfused-viable and reperfused-infarcted myocardium. Thus, metabolic data obtained with P-31 MR spectroscopy permit effective separation of reperfused-viable from reperfused-infarcted myocardium.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalRadiology
Volume172
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Myocardium
Magnetic Resonance Spectroscopy
Phosphocreatine
Coronary Occlusion
Logistic Models
Adenine Nucleotides
Phosphorus
Reperfusion
Canidae
Coronary Vessels
Adenosine Triphosphate
Phosphates
Regression Analysis
Staining and Labeling

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Rehr, R. B., Tatum, J. L., Hirsch, J. I., Quint, R., & Clarke, G. D. (1989). Reperfused-viable and reperfused-infarcted myocardium: Differentiation with in vivo P-31 MR spectroscopy. Radiology, 172(1), 53-58.

Reperfused-viable and reperfused-infarcted myocardium : Differentiation with in vivo P-31 MR spectroscopy. / Rehr, R. B.; Tatum, J. L.; Hirsch, J. I.; Quint, R.; Clarke, Geoffrey D.

In: Radiology, Vol. 172, No. 1, 1989, p. 53-58.

Research output: Contribution to journalArticle

Rehr, RB, Tatum, JL, Hirsch, JI, Quint, R & Clarke, GD 1989, 'Reperfused-viable and reperfused-infarcted myocardium: Differentiation with in vivo P-31 MR spectroscopy', Radiology, vol. 172, no. 1, pp. 53-58.
Rehr, R. B. ; Tatum, J. L. ; Hirsch, J. I. ; Quint, R. ; Clarke, Geoffrey D. / Reperfused-viable and reperfused-infarcted myocardium : Differentiation with in vivo P-31 MR spectroscopy. In: Radiology. 1989 ; Vol. 172, No. 1. pp. 53-58.
@article{d13e9ec5b1574ba08d00376434600d08,
title = "Reperfused-viable and reperfused-infarcted myocardium: Differentiation with in vivo P-31 MR spectroscopy",
abstract = "The ability of in vivo phosphorus-31 magnetic resonance (MR) spectroscopy to permit accurate distinction between reperfused-viable and reperfused-infarcted myocardium was examined in a canine model of acute coronary occlusion. In vivo myocardial pH and phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were measured at baseline and for the first 90 minutes after reperfusion of a total coronary artery occlusion producing either predominantly viable (nine animals) or infarcted (nine animals) myocardium in the region of metabolic study. Myocardial viability was assessed in each animal by means of postmortem triphenyltetrazolium chloride staining. Tissue was characterized from the in vivo P-31 MR data by means of logistic regression analysis. The accuracy of using the P-31 MR data for distinguishing reperfused-viable from reperfused-infarcted myocardium was 100{\%} (69 of 69 data points, 18 of 18 animals). Results of the logistic regression procedure indicated that phosphocreatine was the metabolic variable enabling most effective separation of reperfused-viable and reperfused-infarcted myocardium. Thus, metabolic data obtained with P-31 MR spectroscopy permit effective separation of reperfused-viable from reperfused-infarcted myocardium.",
author = "Rehr, {R. B.} and Tatum, {J. L.} and Hirsch, {J. I.} and R. Quint and Clarke, {Geoffrey D}",
year = "1989",
language = "English (US)",
volume = "172",
pages = "53--58",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Reperfused-viable and reperfused-infarcted myocardium

T2 - Differentiation with in vivo P-31 MR spectroscopy

AU - Rehr, R. B.

AU - Tatum, J. L.

AU - Hirsch, J. I.

AU - Quint, R.

AU - Clarke, Geoffrey D

PY - 1989

Y1 - 1989

N2 - The ability of in vivo phosphorus-31 magnetic resonance (MR) spectroscopy to permit accurate distinction between reperfused-viable and reperfused-infarcted myocardium was examined in a canine model of acute coronary occlusion. In vivo myocardial pH and phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were measured at baseline and for the first 90 minutes after reperfusion of a total coronary artery occlusion producing either predominantly viable (nine animals) or infarcted (nine animals) myocardium in the region of metabolic study. Myocardial viability was assessed in each animal by means of postmortem triphenyltetrazolium chloride staining. Tissue was characterized from the in vivo P-31 MR data by means of logistic regression analysis. The accuracy of using the P-31 MR data for distinguishing reperfused-viable from reperfused-infarcted myocardium was 100% (69 of 69 data points, 18 of 18 animals). Results of the logistic regression procedure indicated that phosphocreatine was the metabolic variable enabling most effective separation of reperfused-viable and reperfused-infarcted myocardium. Thus, metabolic data obtained with P-31 MR spectroscopy permit effective separation of reperfused-viable from reperfused-infarcted myocardium.

AB - The ability of in vivo phosphorus-31 magnetic resonance (MR) spectroscopy to permit accurate distinction between reperfused-viable and reperfused-infarcted myocardium was examined in a canine model of acute coronary occlusion. In vivo myocardial pH and phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were measured at baseline and for the first 90 minutes after reperfusion of a total coronary artery occlusion producing either predominantly viable (nine animals) or infarcted (nine animals) myocardium in the region of metabolic study. Myocardial viability was assessed in each animal by means of postmortem triphenyltetrazolium chloride staining. Tissue was characterized from the in vivo P-31 MR data by means of logistic regression analysis. The accuracy of using the P-31 MR data for distinguishing reperfused-viable from reperfused-infarcted myocardium was 100% (69 of 69 data points, 18 of 18 animals). Results of the logistic regression procedure indicated that phosphocreatine was the metabolic variable enabling most effective separation of reperfused-viable and reperfused-infarcted myocardium. Thus, metabolic data obtained with P-31 MR spectroscopy permit effective separation of reperfused-viable from reperfused-infarcted myocardium.

UR - http://www.scopus.com/inward/record.url?scp=0024393703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024393703&partnerID=8YFLogxK

M3 - Article

C2 - 2740521

AN - SCOPUS:0024393703

VL - 172

SP - 53

EP - 58

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -