Renin-angiotensin-aldosterone system and migraine: A systematic review of human studies

Karina Lúcia Moreira Sassi, Laís Bhering Martins, Aline Silva de Miranda, Antonio Lucio Teixeira

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.

Original languageEnglish (US)
Pages (from-to)512-519
Number of pages8
JournalProtein and Peptide Letters
Issue number6
StatePublished - 2020
Externally publishedYes


  • Aldosterone
  • Angiotensin
  • Genetics
  • Headache
  • Migraine
  • Renin

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry


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