TY - JOUR
T1 - Renin-angiotensin-aldosterone system and migraine
T2 - A systematic review of human studies
AU - Sassi, Karina Lúcia Moreira
AU - Martins, Laís Bhering
AU - Miranda, Aline Silva de
AU - Teixeira, Antonio Lucio
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.
AB - Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.
KW - Aldosterone
KW - Angiotensin
KW - Genetics
KW - Headache
KW - Migraine
KW - Renin
UR - http://www.scopus.com/inward/record.url?scp=85086341042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086341042&partnerID=8YFLogxK
U2 - 10.2174/0929866527666200129160136
DO - 10.2174/0929866527666200129160136
M3 - Review article
C2 - 31995000
AN - SCOPUS:85086341042
SN - 0929-8665
VL - 27
SP - 512
EP - 519
JO - Protein and Peptide Letters
JF - Protein and Peptide Letters
IS - 6
ER -