Abstract
THE RAD10 gene of Saccharomyces cerevisiae is required for the incision step of excision repair of ultraviolet-damaged DNA (refs 1, 2), and it functions in mitotic recombination3. RAD10 has homology to the human excision repair gene ERCC-1 (ref.4). Here we describe the purification of the protein encoded by RAD10 and show that it is a DNA-binding protein with a strong preference for single-stranded DNA. We also show that RAD1O promotes the renaturation of complementary DNA strands.
Original language | English (US) |
---|---|
Pages (from-to) | 743-745 |
Number of pages | 3 |
Journal | Nature |
Volume | 355 |
Issue number | 6362 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General