Renal toxicity of the carcinogen δ-aminolevulinic acid: Antioxidant effects of melatonin

Malgorzata Karbownik; Dun xian Tan; Lucien C. Manchester; Russel J. Reiter

doi:10.1016/S0304-3835(00)00568-1

Renal toxicity of the carcinogen δ-aminolevulinic acid: Antioxidant effects of melatonin

Malgorzata Karbownik, Dun xian Tan, Lucien C. Manchester, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

An increased incidence of cancer in patients suffering from acute intermittent porphyria (AIP) is thought to be related to δ-aminolevulinic acid (ALA) accumulation. Chronic treatment with ALA augmented 8-oxo-7,8-dihydro-2'-deoxyguanosine levels, decreased microsomal and mitochondrial membrane fluidity and increased lipid peroxidation in blood serum. Co-treatment with melatonin completely counteracted the effects of ALA. Melatonin effectively protects DNA and microsomal and mitochondrial membranes in rat kidney from oxidative damage due to ALA. Because of its low toxicity and anticarcinogenic properties, melatonin could be tested as an agent to reduce oxidative damage in patients with AIP. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Cancer Letters
Volume	161
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(00)00568-1
State	Published - Dec 8 2000

Keywords

Cancer
DNA
Melatonin
Microsomal and mitochondrial membranes
Oxidative damage
δ-Aminolevulinic acid

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(00)00568-1

Cite this

@article{28074a10fed34253982c1d486694000e,

title = "Renal toxicity of the carcinogen δ-aminolevulinic acid: Antioxidant effects of melatonin",

abstract = "An increased incidence of cancer in patients suffering from acute intermittent porphyria (AIP) is thought to be related to δ-aminolevulinic acid (ALA) accumulation. Chronic treatment with ALA augmented 8-oxo-7,8-dihydro-2'-deoxyguanosine levels, decreased microsomal and mitochondrial membrane fluidity and increased lipid peroxidation in blood serum. Co-treatment with melatonin completely counteracted the effects of ALA. Melatonin effectively protects DNA and microsomal and mitochondrial membranes in rat kidney from oxidative damage due to ALA. Because of its low toxicity and anticarcinogenic properties, melatonin could be tested as an agent to reduce oxidative damage in patients with AIP. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Cancer, DNA, Melatonin, Microsomal and mitochondrial membranes, Oxidative damage, δ-Aminolevulinic acid",

author = "Malgorzata Karbownik and Tan, {Dun xian} and Manchester, {Lucien C.} and Reiter, {Russel J.}",

note = "Funding Information: Ma{\l}gorzata Karbownik was supported by an American Cancer Society International Fellowship for Beginning Investigators. Research was supported in part by a grant from Amoun Pharmaceutical Company. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "2000",

month = dec,

day = "8",

doi = "10.1016/S0304-3835(00)00568-1",

language = "English (US)",

volume = "161",

pages = "1--7",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Renal toxicity of the carcinogen δ-aminolevulinic acid

T2 - Antioxidant effects of melatonin

AU - Karbownik, Malgorzata

AU - Tan, Dun xian

AU - Manchester, Lucien C.

AU - Reiter, Russel J.

N1 - Funding Information: Małgorzata Karbownik was supported by an American Cancer Society International Fellowship for Beginning Investigators. Research was supported in part by a grant from Amoun Pharmaceutical Company. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2000/12/8

Y1 - 2000/12/8

N2 - An increased incidence of cancer in patients suffering from acute intermittent porphyria (AIP) is thought to be related to δ-aminolevulinic acid (ALA) accumulation. Chronic treatment with ALA augmented 8-oxo-7,8-dihydro-2'-deoxyguanosine levels, decreased microsomal and mitochondrial membrane fluidity and increased lipid peroxidation in blood serum. Co-treatment with melatonin completely counteracted the effects of ALA. Melatonin effectively protects DNA and microsomal and mitochondrial membranes in rat kidney from oxidative damage due to ALA. Because of its low toxicity and anticarcinogenic properties, melatonin could be tested as an agent to reduce oxidative damage in patients with AIP. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - An increased incidence of cancer in patients suffering from acute intermittent porphyria (AIP) is thought to be related to δ-aminolevulinic acid (ALA) accumulation. Chronic treatment with ALA augmented 8-oxo-7,8-dihydro-2'-deoxyguanosine levels, decreased microsomal and mitochondrial membrane fluidity and increased lipid peroxidation in blood serum. Co-treatment with melatonin completely counteracted the effects of ALA. Melatonin effectively protects DNA and microsomal and mitochondrial membranes in rat kidney from oxidative damage due to ALA. Because of its low toxicity and anticarcinogenic properties, melatonin could be tested as an agent to reduce oxidative damage in patients with AIP. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Cancer

KW - DNA

KW - Melatonin

KW - Microsomal and mitochondrial membranes

KW - Oxidative damage

KW - δ-Aminolevulinic acid

UR - http://www.scopus.com/inward/record.url?scp=0034624312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034624312&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(00)00568-1

DO - 10.1016/S0304-3835(00)00568-1

M3 - Article

C2 - 11078907

AN - SCOPUS:0034624312

SN - 0304-3835

VL - 161

SP - 1

EP - 7

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Renal toxicity of the carcinogen δ-aminolevulinic acid: Antioxidant effects of melatonin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this