Renal toxicity of the carcinogen δ-aminolevulinic acid: Antioxidant effects of melatonin

Malgorzata Karbownik, Dun xian Tan, Lucien C. Manchester, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

An increased incidence of cancer in patients suffering from acute intermittent porphyria (AIP) is thought to be related to δ-aminolevulinic acid (ALA) accumulation. Chronic treatment with ALA augmented 8-oxo-7,8-dihydro-2'-deoxyguanosine levels, decreased microsomal and mitochondrial membrane fluidity and increased lipid peroxidation in blood serum. Co-treatment with melatonin completely counteracted the effects of ALA. Melatonin effectively protects DNA and microsomal and mitochondrial membranes in rat kidney from oxidative damage due to ALA. Because of its low toxicity and anticarcinogenic properties, melatonin could be tested as an agent to reduce oxidative damage in patients with AIP. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCancer Letters
Volume161
Issue number1
DOIs
StatePublished - Dec 8 2000

Keywords

  • Cancer
  • DNA
  • Melatonin
  • Microsomal and mitochondrial membranes
  • Oxidative damage
  • δ-Aminolevulinic acid

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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