Renal sodium-glucose transport: Role in diabetes mellitus and potential clinical implications

George L. Bakris, Vivian A. Fonseca, Kumar Sharma, Ernest M. Wright

Research output: Contribution to journalReview article

203 Citations (Scopus)

Abstract

The kidneys play a major role in the regulation of glucose in humans, reabsorbing 99% of the plasma glucose that filters through the renal glomeruli tubules. The glucose transporter, SGLT2, which is found primarily in the S1 segment of the proximal renal tubule, is essential to this process, accounting for 90% of the glucose reabsorption in the kidney. Evidence has suggested that selective inhibition of SGLT2 induces glucosuria in a dose-dependent manner and may have beneficial effects on glucose regulation in individuals with type II diabetes. Preclinical data with SGLT2 inhibitors, such as dapagliflozin and sergliflozin, show that these compounds are highly selective inhibitors for SGLT2, have beneficial effects on the glucose utilization rate, and reduce hyperglycemia while having no hypoglycemic adverse effects. Clinical research remains to be carried out on the long-term effects of glucosuria and other potential effects of this class of drug. Nonetheless, these compounds represent a very promising approach for the treatment of diabetes.

Original languageEnglish (US)
Pages (from-to)1272-1277
Number of pages6
JournalKidney International
Volume75
Issue number12
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Diabetes Mellitus
Sodium
Kidney
Glucose
Proximal Kidney Tubule
Facilitative Glucose Transport Proteins
Hypoglycemic Agents
Hyperglycemia
Type 2 Diabetes Mellitus
Research
Pharmaceutical Preparations

Keywords

  • Diabetes
  • Glucose
  • Glycosuria
  • Hyperglycemia
  • Kidney
  • Transport

ASJC Scopus subject areas

  • Nephrology

Cite this

Renal sodium-glucose transport : Role in diabetes mellitus and potential clinical implications. / Bakris, George L.; Fonseca, Vivian A.; Sharma, Kumar; Wright, Ernest M.

In: Kidney International, Vol. 75, No. 12, 01.06.2009, p. 1272-1277.

Research output: Contribution to journalReview article

Bakris, George L. ; Fonseca, Vivian A. ; Sharma, Kumar ; Wright, Ernest M. / Renal sodium-glucose transport : Role in diabetes mellitus and potential clinical implications. In: Kidney International. 2009 ; Vol. 75, No. 12. pp. 1272-1277.
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