Renal histopathology of a baboon model with type 2 diabetes

Hernan Rincon-Choles, Hanna E. Abboud, Shuko Lee, Robert E. Shade, Karen S. Rice, K. Dee Carey, Anthony G. Comuzzie, Jeffrey L. Barnes

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Naturally occurring type 2 diabetes has been found in a colony of baboons. Ongoing characterization of the baboon colony maintained at the Southwest National Primate Research Center has revealed a significant range of glucose sensitivity with some animals clearly diabetic. Seven baboons, four with diabetes and three without diabetes, underwent histopathological investigation. Three diabetic animals were diagnosed using fasting blood glucose, hemoglobin A1C, and intravenous glucose tolerance test, and a fourth one was known to have hyperglycemia. One control baboon and three baboons with diabetes had microalbuminuria. On kidney biopsy, diabetic baboons had thickening of the glomerular basement membrane and mesangial matrix expansion compared to controls. Immunohistochemistry showed the diabetic animals had increased mesangial expression of cellular fibronectin ED-A. Two diabetic animals with microalbuminuria had evidence of mesangiolysis with the formation of an early nodule. One diabetic animal had a Kimmestiel-Wilson nodule. We conclude that the baboon represents a useful primate model of diabetes and nephropathy that resembles the nephropathy associated with type 2 diabetes in humans.

Original languageEnglish (US)
Pages (from-to)1020-1030
Number of pages11
JournalToxicologic Pathology
Volume40
Issue number7
DOIs
StatePublished - Oct 2012

Keywords

  • baboon
  • diabetic nephropathy
  • glomerular basement membrane
  • mesangium
  • renal morphology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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