Renal dysfunction in heart failure patients: What is the evidence?

Heath E. Saltzman, Kumar Sharma, Paul J. Mather, Sharon Rubin, Suzanne Adams, David Joshua Whellan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Congestive heart failure (CHF) is an increasingly common medical condition and the fastest growing cardiovascular diagnosis in North America. Over one-third of patients with heart failure also have renal insufficiency. It has been shown that renal insufficiency confers worsened outcomes to patients with heart failure. However, a majority of the larger and therapy-defining heart failure medication and device trials exclude patients with advanced renal dysfunction. These studies also infrequently perform subgroup analyses based on the degree of renal dysfunction. The lack of information on heart failure patients who have renal insufficiency likely contributes to their being prescribed mortality and morbidity reducing medications and receiving diagnostic and therapeutic procedures at lower rates than heart failure patients with normal renal function. Inclusion of patients with renal insufficiency in heart failure studies and published guidelines for medication, device, and interventional therapies would likely improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalHeart Failure Reviews
Issue number1
StatePublished - Mar 2007
Externally publishedYes


  • Heart failure
  • Renal dysfunction
  • Worsened outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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