Renal Cell Carcinoma: Recent Advances in Genetics and Imaging

Shaile Choudhary, Sunil Sudarshan, Peter L. Choyke, Srinivasa R. Prasad

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Recent advances in molecular biology and cytogenetics have provided unique insights into the ontogeny, pathogenesis, and biological behavior of renal cell carcinoma. Renal cell carcinoma is now known to be a polymorphic malignant neoplasm consisting of several histologic subtypes demonstrating different biological profiles. Clear cell renal carcinoma, the most common histologic subtype, is predominantly associated with mutations involving the von Hippel-Lindau gene and elaboration of vascular and somatic growth factors. Clear cell renal cell carcinoma is thus typically hypervascular at imaging. By contrast, papillary renal cell carcinoma, the second most common subtype, is frequently hypovascular. Current molecular data on the biology of renal neoplasms have shown important diagnostic, therapeutic, and prognostic implications. Comprehensive knowledge of molecular pathways of carcinogenesis of renal cancers has allowed design of rational treatment protocols and posttreatment surveillance algorithms, thereby permitting optimal patient management.

Original languageEnglish (US)
Pages (from-to)315-325
Number of pages11
JournalSeminars in Ultrasound, CT and MRI
Volume30
Issue number4
DOIs
StatePublished - Aug 2009

Fingerprint

Renal Cell Carcinoma
Kidney Neoplasms
Clinical Protocols
Cytogenetics
Blood Vessels
Molecular Biology
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Mutation
Genes
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Renal Cell Carcinoma : Recent Advances in Genetics and Imaging. / Choudhary, Shaile; Sudarshan, Sunil; Choyke, Peter L.; Prasad, Srinivasa R.

In: Seminars in Ultrasound, CT and MRI, Vol. 30, No. 4, 08.2009, p. 315-325.

Research output: Contribution to journalArticle

Choudhary, S, Sudarshan, S, Choyke, PL & Prasad, SR 2009, 'Renal Cell Carcinoma: Recent Advances in Genetics and Imaging', Seminars in Ultrasound, CT and MRI, vol. 30, no. 4, pp. 315-325. https://doi.org/10.1053/j.sult.2009.03.003
Choudhary, Shaile ; Sudarshan, Sunil ; Choyke, Peter L. ; Prasad, Srinivasa R. / Renal Cell Carcinoma : Recent Advances in Genetics and Imaging. In: Seminars in Ultrasound, CT and MRI. 2009 ; Vol. 30, No. 4. pp. 315-325.
@article{abe2c8a788b1446db1b1e5d8cf96d4cf,
title = "Renal Cell Carcinoma: Recent Advances in Genetics and Imaging",
abstract = "Recent advances in molecular biology and cytogenetics have provided unique insights into the ontogeny, pathogenesis, and biological behavior of renal cell carcinoma. Renal cell carcinoma is now known to be a polymorphic malignant neoplasm consisting of several histologic subtypes demonstrating different biological profiles. Clear cell renal carcinoma, the most common histologic subtype, is predominantly associated with mutations involving the von Hippel-Lindau gene and elaboration of vascular and somatic growth factors. Clear cell renal cell carcinoma is thus typically hypervascular at imaging. By contrast, papillary renal cell carcinoma, the second most common subtype, is frequently hypovascular. Current molecular data on the biology of renal neoplasms have shown important diagnostic, therapeutic, and prognostic implications. Comprehensive knowledge of molecular pathways of carcinogenesis of renal cancers has allowed design of rational treatment protocols and posttreatment surveillance algorithms, thereby permitting optimal patient management.",
author = "Shaile Choudhary and Sunil Sudarshan and Choyke, {Peter L.} and Prasad, {Srinivasa R.}",
year = "2009",
month = "8",
doi = "10.1053/j.sult.2009.03.003",
language = "English (US)",
volume = "30",
pages = "315--325",
journal = "Seminars in Ultrasound, CT and MRI",
issn = "0887-2171",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Renal Cell Carcinoma

T2 - Recent Advances in Genetics and Imaging

AU - Choudhary, Shaile

AU - Sudarshan, Sunil

AU - Choyke, Peter L.

AU - Prasad, Srinivasa R.

PY - 2009/8

Y1 - 2009/8

N2 - Recent advances in molecular biology and cytogenetics have provided unique insights into the ontogeny, pathogenesis, and biological behavior of renal cell carcinoma. Renal cell carcinoma is now known to be a polymorphic malignant neoplasm consisting of several histologic subtypes demonstrating different biological profiles. Clear cell renal carcinoma, the most common histologic subtype, is predominantly associated with mutations involving the von Hippel-Lindau gene and elaboration of vascular and somatic growth factors. Clear cell renal cell carcinoma is thus typically hypervascular at imaging. By contrast, papillary renal cell carcinoma, the second most common subtype, is frequently hypovascular. Current molecular data on the biology of renal neoplasms have shown important diagnostic, therapeutic, and prognostic implications. Comprehensive knowledge of molecular pathways of carcinogenesis of renal cancers has allowed design of rational treatment protocols and posttreatment surveillance algorithms, thereby permitting optimal patient management.

AB - Recent advances in molecular biology and cytogenetics have provided unique insights into the ontogeny, pathogenesis, and biological behavior of renal cell carcinoma. Renal cell carcinoma is now known to be a polymorphic malignant neoplasm consisting of several histologic subtypes demonstrating different biological profiles. Clear cell renal carcinoma, the most common histologic subtype, is predominantly associated with mutations involving the von Hippel-Lindau gene and elaboration of vascular and somatic growth factors. Clear cell renal cell carcinoma is thus typically hypervascular at imaging. By contrast, papillary renal cell carcinoma, the second most common subtype, is frequently hypovascular. Current molecular data on the biology of renal neoplasms have shown important diagnostic, therapeutic, and prognostic implications. Comprehensive knowledge of molecular pathways of carcinogenesis of renal cancers has allowed design of rational treatment protocols and posttreatment surveillance algorithms, thereby permitting optimal patient management.

UR - http://www.scopus.com/inward/record.url?scp=67649889980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649889980&partnerID=8YFLogxK

U2 - 10.1053/j.sult.2009.03.003

DO - 10.1053/j.sult.2009.03.003

M3 - Article

C2 - 19711643

AN - SCOPUS:67649889980

VL - 30

SP - 315

EP - 325

JO - Seminars in Ultrasound, CT and MRI

JF - Seminars in Ultrasound, CT and MRI

SN - 0887-2171

IS - 4

ER -