Renal blood flow changes following mannitol infusion.

W. R. Castaneda-Zuniga, V. Janata, I. Beranek, K. Amplatz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of mannitol infusion on the renal physiology, was evaluated in experimental animals and in man. In animals plasma flow and glomerular filtration rate were determined by the PAH extraction and by the innulin clearance technique. In patients renal blood flow measurements were carried out using the Xenon133 washout technique. Baseline studies were obtained and repeated following the intravenous infusion of 20% mannitol. A significant increase in total renal blood flow could be demonstrated in experimental animals, but only a minimal increase of total flow was demonstrated in man following the infusion of mannitol. This observation suggests that the diuretic effect of mannitol is very likely due to the osmotic effect in the tubule causing increased interstitial renal pressure rather than by an increase of actual renal blood flow. This observation is supported by the clinical experience that mannitol remains a powerful diuretic in even hypotensive patients with low renal blood flow.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalRevista interamericana de radiologia
Volume3
Issue number1
StatePublished - Jan 1978
Externally publishedYes

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Renal Circulation
Mannitol
Diuretics
Kidney
Glomerular Filtration Rate
Intravenous Infusions
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Castaneda-Zuniga, W. R., Janata, V., Beranek, I., & Amplatz, K. (1978). Renal blood flow changes following mannitol infusion. Revista interamericana de radiologia, 3(1), 21-26.

Renal blood flow changes following mannitol infusion. / Castaneda-Zuniga, W. R.; Janata, V.; Beranek, I.; Amplatz, K.

In: Revista interamericana de radiologia, Vol. 3, No. 1, 01.1978, p. 21-26.

Research output: Contribution to journalArticle

Castaneda-Zuniga, WR, Janata, V, Beranek, I & Amplatz, K 1978, 'Renal blood flow changes following mannitol infusion.', Revista interamericana de radiologia, vol. 3, no. 1, pp. 21-26.
Castaneda-Zuniga WR, Janata V, Beranek I, Amplatz K. Renal blood flow changes following mannitol infusion. Revista interamericana de radiologia. 1978 Jan;3(1):21-26.
Castaneda-Zuniga, W. R. ; Janata, V. ; Beranek, I. ; Amplatz, K. / Renal blood flow changes following mannitol infusion. In: Revista interamericana de radiologia. 1978 ; Vol. 3, No. 1. pp. 21-26.
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