Renal artery plaque composition is associated with changes in renal frame count following renal artery stenting

Anand Prasad, Manjusha Ilapakurti, Patrick Hu, Nayab Zafar, Vachaspathi Palakodeti, Sotirios Tsimikas, Ehtisham Mahmud

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Benefit of percutaneous revascularization for atherosclerotic renal artery stenosis (RAS) may be attenuated by distal embolization of atheroemboli. The purpose of this study was to characterize RAS plaque composition with intravascular ultrasound virtual histology (IVUS-VH) and to explore the relationship between plaque components and renal frame count (RFC) after renal revascularization. METHODS: Seventeen patients (75 ± 7.5 years; 18 lesions) undergoing RAS revascularization were included. Before stenting, automated IVUS-VH pullback (0.5 mm/sec) with analysis of the minimal luminal diameter (MLD) frame and entire atherosclerotic segment was performed. RFC was also determined before and after stenting. Results: The VH component analysis of the segment demonstrated predominantly fibrous tissue (56.3 ± 11.4), followed by necrotic core (21.8 ± 8.6), dense calcification (13.2 ± 6.6) and fibrofatty tissue (8.7 ± 4.0). Analysis of the MLD frame also demonstrated mostly fibrous tissue (62.1 ± 11.1), with smaller amounts of necrotic core (15.6 ± 7.3), fibrofatty (13.9 ± 9.6), and dense calcification (8.4 ± 6.0). A trend toward more fibrous tissue (p ≤ 0.074), less necrotic core (p ≤ 0.095) and less dense calcification (p ≤ 0.075) at the MLD compared to the segment was observed. Analysis of the entire atherosclerotic segment revealed a positive correlation between necrotic core and change in RFC (r ≤ 0.582; p ≤ 0.029), with increasing necrotic core associated with an increase in RFC after revascularization. Conclusion: Both the MLD frame and segmental analysis of atherosclerotic RAS lesions demonstrate predominantly fibrous tissue with smaller amounts of necrotic core, fibrofatty tissue, and dense calcification. Increased necrotic core correlates with a lack of improvement in RFC after stenting.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalJournal of Invasive Cardiology
Issue number6
StatePublished - Jun 2011
Externally publishedYes


  • hypertension
  • intravascular ultrasound
  • renal stent
  • virtual histology

ASJC Scopus subject areas

  • General Medicine


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