Remineralization Strategies for Teeth with Molar Incisor Hypomineralization (MIH): A Literature Review

Joachim Enax, Bennett T. Amaechi, Rayane Farah, Jungyi Alexis Liu, Erik Schulze zur Wiesche, Frederic Meyer

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Molar incisor hypomineralization (MIH) is a highly prevalent dental developmental disorder with a significant health burden for patients and high treatment needs, yet no comprehensive review article on all remineralization systems as a non-invasive treatment approach for MIH has been published. Typical characteristics of MIH-affected teeth are a lower mineral density and lower hardness compared to healthy teeth leading to sensitivity and loss of function. Thus, the use of formulations with calcium phosphates to remineralize MIH-affected teeth is reasonable. This review presents an up-to-date overview of remineralization studies focusing on active ingredients investigated for remineralization of MIH, i.e., casein phosphopeptide amorphous calcium phosphate (CPP-ACP), casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP), hydroxyapatite, calcium glycerophosphate, self-assembling peptide, and fluoride. Overall, 19 studies (in vitro, in situ, and in vivo) were found. Furthermore, an additional search for studies focusing on using toothpaste/dentifrices for MIH management resulted in six studies, where three studies were on remineralization and three on reduction of sensitivity. Overall, the studies analyzed in this review showed that MIH-affected teeth could be remineralized using calcium phosphate-based approaches. In conclusion, calcium phosphates like CPP-ACP, calcium glycerophosphate, and hydroxyapatite can be used to remineralize MIH-affected teeth. In addition to MIH-remineralization, CPP-ACP and hydroxyapatite also offer relief from MIH-associated tooth sensitivity.

Original languageEnglish (US)
Article number80
JournalDentistry Journal
Issue number3
StatePublished - Mar 2023


  • calcium phosphate
  • dentifrice
  • fluoride
  • hydroxyapatite
  • molar incisor hypomineralization (MIH)
  • remineralization
  • sensitivity
  • toothpaste

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'Remineralization Strategies for Teeth with Molar Incisor Hypomineralization (MIH): A Literature Review'. Together they form a unique fingerprint.

Cite this