Remineralization of early caries by a nano-hydroxyapatite dentifrice

K. Najibfard, I. Chedjieu, K. Ramalingam, B. T. Amaechi

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Objective: The purpose of this randomized, double-blind, crossover, in situ study was to evaluate the efficacy of nano-hydroxyapatite (nHAP) dentifrices on caries remineralization and demineralization inhibition. Methods: Three demineralized enamel blocks (A,B,C) and one healthy block (D), cut from each of 30 molars, were exposed respectively to dentifrices of A) 5% nHAP, B) 10% nHAP, C) 1100 ppm fluoride, and D) 10% nHAP via an intra-oral appliance worn by 30 adults in this four-phase study lasting 28 days per phase. Baseline and post-test mineral loss (ΔZ) and lesion depth (LD) were quantified using microradiography. Results: Pair-wise comparison (baseline versus test) demonstrated significant (p < 0.001) reductions in ΔZ and LD in A, B, and C. ANOVA showed no significant differences among the three products in percent mineral gain. No demineralization occurred in the sound enamel specimens exposed intra-orally while using 10% nHAP. Conclusion: nHAP dentifrice caused remineralization comparable to a fluoride dentifrice, and inhibited caries development, thus suggesting that an nHAP dentifrice can be an effective alternative to fluoride toothpaste.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalJournal of Clinical Dentistry
Volume22
Issue number5
StatePublished - Nov 29 2011

ASJC Scopus subject areas

  • Dentistry(all)

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