Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design

Paul W.H.I. Parren, Marie Claire Gauduin, Richard A. Koup, Pascal Poignard, Paola Fisicaro, Dennis R. Burton, Quentin J. Sattentau

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    47 Scopus citations

    Abstract

    Understanding the antibody response in HIV-1 infection is important to vaccine design. We have studied the antibody response to HIV-1 envelope at the molecular level and determined the characteristics of neutralizing and non-neutralizing antibodies. These antibodies were isolated from phage display libraries prepared from long-term seropositive asymptomatic individuals. The HIV-1 envelope is presented to the immune system in several antigenically distinct configurations: unprocessed gp160, gp120 and gp41 subunits and native envelope, each of which may be important in eliciting an antibody response in HIV-1 infection. The antibodies tested characteristically had poor affinities for native envelope as expressed on the surface of virions or infected cells, but had high affinities against non-native forms of HIV-1 envelope (viral debris). An exceptionally potent neutralizing antibody in contrast, bound native envelope with equivalent or somewhat higher affinity than this. This indicates that the antibody response in HIV-1 infection is principally elicited by viral debris rather than virions, and that these antibodies bind and neutralize viruses sub-optimally. Potential vaccines should be designed to elicit responses against native envelope.

    Original languageEnglish (US)
    Pages (from-to)105-112
    Number of pages8
    JournalImmunology Letters
    Volume57
    Issue number1-3
    DOIs
    StatePublished - Aug 12 1997

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    Keywords

    • Antibody response
    • Human immunodeficiency virus type 1
    • Vaccine design

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

    Cite this

    Parren, P. W. H. I., Gauduin, M. C., Koup, R. A., Poignard, P., Fisicaro, P., Burton, D. R., & Sattentau, Q. J. (1997). Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. Immunology Letters, 57(1-3), 105-112. https://doi.org/10.1016/S0165-2478(97)00043-6