TY - JOUR
T1 - Relationship of transfusion and infection in a burn population
AU - Graves, Theresa A.
AU - Cioffi, William G.
AU - Mason, Arthur D.
AU - McManus, William F.
AU - Pruitt, Basil A.
PY - 1989/7
Y1 - 1989/7
N2 - The relationship between the number of red blood cell transfusions and major infectious complications was evaluated in 594 thermal injury patients admitted between 1982 and 1986 who had burns over 10% or more of total body surface area and survived more than 10 days. The mean age of this group was 32.9 years, with a mean burn size of 36% of total body surface area; 83% were male. Of the 594 patients, 23.7% died and 38.7% had documented inhalation injury. The mean number of red blood cell transfusions received was 19.7, with a range of 0 to 201. Two hundred fourteen patients (36%) had major infectious complications, defined as pneumonia or invasive burn wound infection. A cross-tabulation of predicted mortality, number of transfusions, and infectious complications revealed a significant positive correlation between transfusion number and infectious complications in patients with predicted mortalities between 10 and 70%. Per cent total burn, patient age, presence of inhalation injury, and number of transfusions were identified by discriminant function analysis as significant variables (p < 0.05) in discriminating between patients with and without infections (85% accuracy). Logistic regression analysis confirmed the above findings, showing a relationship between the number of transfusions received and infectious morbidity which was independent of age or burn size, but no significant relationship between number of transfusions and mortality.
AB - The relationship between the number of red blood cell transfusions and major infectious complications was evaluated in 594 thermal injury patients admitted between 1982 and 1986 who had burns over 10% or more of total body surface area and survived more than 10 days. The mean age of this group was 32.9 years, with a mean burn size of 36% of total body surface area; 83% were male. Of the 594 patients, 23.7% died and 38.7% had documented inhalation injury. The mean number of red blood cell transfusions received was 19.7, with a range of 0 to 201. Two hundred fourteen patients (36%) had major infectious complications, defined as pneumonia or invasive burn wound infection. A cross-tabulation of predicted mortality, number of transfusions, and infectious complications revealed a significant positive correlation between transfusion number and infectious complications in patients with predicted mortalities between 10 and 70%. Per cent total burn, patient age, presence of inhalation injury, and number of transfusions were identified by discriminant function analysis as significant variables (p < 0.05) in discriminating between patients with and without infections (85% accuracy). Logistic regression analysis confirmed the above findings, showing a relationship between the number of transfusions received and infectious morbidity which was independent of age or burn size, but no significant relationship between number of transfusions and mortality.
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U2 - 10.1097/00005373-198907000-00007
DO - 10.1097/00005373-198907000-00007
M3 - Article
C2 - 2746705
AN - SCOPUS:0024338202
VL - 29
SP - 948
EP - 954
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 7
ER -