Abstract
Previous data have indicated that decreased sex hormone binding globulin (SHBG) is associated with increased overall and upper body adiposity and higher levels of glucose, insulin and triglyceride (TG) and decreased levels of high-density lipoprotein (HDL) cholesterol. Since Mexican Americans have greater overall and upper body adiposity, higher rates of non-insulin-dependent diabetes mellitus, higher TG and lower HDL levels than non-Hispanic whites, we postulated that they would also have lower levels of SHBG. We measured total testosterone and total estradiol using a commercial radioimmunoassay and SHBG using a dextran-coated technique in premenopausal women (61 Mexican American and 39 non-Hispanic white) as part of the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. There were no significant ethnic differences in total testosterone or total estradiol. SHBG, however, was lower in Mexican American (0.285 μg/dl) than in non-Hispanic white women (0.429 μg/dl) (P = 0.009). After adjustment for body mass index (BMI), ratio of waist-to-hip circumference (WHR) and ratio of subscapular-to-triceps skinfolds (centrality index), SHBG remained lower in Mexican Americans (O.307 μg/dl) than in non-Hispanic whites (0.396 μg/dl), although this difference was no longer statistically significant (P = 0.083). BMI, WHR and centrality index were all negative associated with SHBG (P < 0.01). The lower levels of SHBG in premenopausal Mexican American women compared to non-Hispanic white women may reflect greater in-vivo androgenicity and may be related to a variety of metabolic abnormalities seen in this ethnic group.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | International Journal of Obesity |
| Volume | 13 |
| Issue number | 1 |
| State | Published - 1989 |
Fingerprint
ASJC Scopus subject areas
- Food Science
- Endocrinology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Public Health, Environmental and Occupational Health
Cite this
Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population. / Haffner, S. M.; Katz, M. S.; Stern, M. P.; Dunn, J. F.
In: International Journal of Obesity, Vol. 13, No. 1, 1989, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population
AU - Haffner, S. M.
AU - Katz, M. S.
AU - Stern, M. P.
AU - Dunn, J. F.
PY - 1989
Y1 - 1989
N2 - Previous data have indicated that decreased sex hormone binding globulin (SHBG) is associated with increased overall and upper body adiposity and higher levels of glucose, insulin and triglyceride (TG) and decreased levels of high-density lipoprotein (HDL) cholesterol. Since Mexican Americans have greater overall and upper body adiposity, higher rates of non-insulin-dependent diabetes mellitus, higher TG and lower HDL levels than non-Hispanic whites, we postulated that they would also have lower levels of SHBG. We measured total testosterone and total estradiol using a commercial radioimmunoassay and SHBG using a dextran-coated technique in premenopausal women (61 Mexican American and 39 non-Hispanic white) as part of the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. There were no significant ethnic differences in total testosterone or total estradiol. SHBG, however, was lower in Mexican American (0.285 μg/dl) than in non-Hispanic white women (0.429 μg/dl) (P = 0.009). After adjustment for body mass index (BMI), ratio of waist-to-hip circumference (WHR) and ratio of subscapular-to-triceps skinfolds (centrality index), SHBG remained lower in Mexican Americans (O.307 μg/dl) than in non-Hispanic whites (0.396 μg/dl), although this difference was no longer statistically significant (P = 0.083). BMI, WHR and centrality index were all negative associated with SHBG (P < 0.01). The lower levels of SHBG in premenopausal Mexican American women compared to non-Hispanic white women may reflect greater in-vivo androgenicity and may be related to a variety of metabolic abnormalities seen in this ethnic group.
AB - Previous data have indicated that decreased sex hormone binding globulin (SHBG) is associated with increased overall and upper body adiposity and higher levels of glucose, insulin and triglyceride (TG) and decreased levels of high-density lipoprotein (HDL) cholesterol. Since Mexican Americans have greater overall and upper body adiposity, higher rates of non-insulin-dependent diabetes mellitus, higher TG and lower HDL levels than non-Hispanic whites, we postulated that they would also have lower levels of SHBG. We measured total testosterone and total estradiol using a commercial radioimmunoassay and SHBG using a dextran-coated technique in premenopausal women (61 Mexican American and 39 non-Hispanic white) as part of the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. There were no significant ethnic differences in total testosterone or total estradiol. SHBG, however, was lower in Mexican American (0.285 μg/dl) than in non-Hispanic white women (0.429 μg/dl) (P = 0.009). After adjustment for body mass index (BMI), ratio of waist-to-hip circumference (WHR) and ratio of subscapular-to-triceps skinfolds (centrality index), SHBG remained lower in Mexican Americans (O.307 μg/dl) than in non-Hispanic whites (0.396 μg/dl), although this difference was no longer statistically significant (P = 0.083). BMI, WHR and centrality index were all negative associated with SHBG (P < 0.01). The lower levels of SHBG in premenopausal Mexican American women compared to non-Hispanic white women may reflect greater in-vivo androgenicity and may be related to a variety of metabolic abnormalities seen in this ethnic group.
UR - http://www.scopus.com/inward/record.url?scp=0024498727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024498727&partnerID=8YFLogxK
M3 - Article
C2 - 2703288
AN - SCOPUS:0024498727
VL - 13
SP - 1
EP - 9
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 1
ER -