Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population

S. M. Haffner, M. S. Katz, M. P. Stern, J. F. Dunn

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Previous data have indicated that decreased sex hormone binding globulin (SHBG) is associated with increased overall and upper body adiposity and higher levels of glucose, insulin and triglyceride (TG) and decreased levels of high-density lipoprotein (HDL) cholesterol. Since Mexican Americans have greater overall and upper body adiposity, higher rates of non-insulin-dependent diabetes mellitus, higher TG and lower HDL levels than non-Hispanic whites, we postulated that they would also have lower levels of SHBG. We measured total testosterone and total estradiol using a commercial radioimmunoassay and SHBG using a dextran-coated technique in premenopausal women (61 Mexican American and 39 non-Hispanic white) as part of the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. There were no significant ethnic differences in total testosterone or total estradiol. SHBG, however, was lower in Mexican American (0.285 μg/dl) than in non-Hispanic white women (0.429 μg/dl) (P = 0.009). After adjustment for body mass index (BMI), ratio of waist-to-hip circumference (WHR) and ratio of subscapular-to-triceps skinfolds (centrality index), SHBG remained lower in Mexican Americans (O.307 μg/dl) than in non-Hispanic whites (0.396 μg/dl), although this difference was no longer statistically significant (P = 0.083). BMI, WHR and centrality index were all negative associated with SHBG (P < 0.01). The lower levels of SHBG in premenopausal Mexican American women compared to non-Hispanic white women may reflect greater in-vivo androgenicity and may be related to a variety of metabolic abnormalities seen in this ethnic group.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Obesity
Volume13
Issue number1
StatePublished - 1989

Fingerprint

Body Fat Distribution
body fat distribution
Sex Hormone-Binding Globulin
Adiposity
adiposity
Mexican Americans
Population
testosterone
body mass index
Testosterone
estradiol
Estradiol
Triglycerides
Body Mass Index
triacylglycerols
ethnic differences
waist-to-hip ratio
Waist-Hip Ratio
waist
high density lipoprotein

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population. / Haffner, S. M.; Katz, M. S.; Stern, M. P.; Dunn, J. F.

In: International Journal of Obesity, Vol. 13, No. 1, 1989, p. 1-9.

Research output: Contribution to journalArticle

Haffner, S. M. ; Katz, M. S. ; Stern, M. P. ; Dunn, J. F. / Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population. In: International Journal of Obesity. 1989 ; Vol. 13, No. 1. pp. 1-9.
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