Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in amultiethnic population: The insulin resistance atherosclerosis study

Carlos Lorenzo, Anthony J.G. Hanley, Lynne E. Wagenknecht, Marian J. Rewers, Darko Stefanovski, Mark O. Goodarzi, Steven M. Haffner

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

OBJECTIVE - We aimed to examine insulin clearance, a compensatory mechanism to changes in insulin sensitivity, across sex, race/ethnicity populations, and varying states of glucose tolerance. RESEARCH DESIGN AND METHODS - We measured insulin sensitivity index (SI), acute insulin response (AIR), and metabolic clearance rate of insulin (MCRI) by the frequently sampled intravenous glucose tolerance test in 1,295 participants in the Insulin Resistance Atherosclerosis Study. RESULTS - MCRI was positively related to S I and negatively to AIR and adiposity across sex, race/ethnicity populations, and varying states of glucose tolerance, adiposity, and family history of diabetes. Differences in MCRI by race/ethnicity (lower in African Americans and Hispanics compared with non-Hispanic whites) and glucose tolerancewere largely explained by differences in adiposity, SI , and AIR. CONCLUSIONS - Insulin sensitivity, insulin secretion, and adiposity are correlates of insulin clearance and appear to explain differences in insulin clearance by race/ethnicity and glucose tolerance status.

Original languageEnglish (US)
Pages (from-to)101-103
Number of pages3
JournalDiabetes care
Volume36
Issue number1
DOIs
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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