Relationship of acute mania symptomatology to maintenance treatment response

Charles L. Bowden

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Most treatment of bipolar disorders addresses maintenance objectives. In the past 4 years, several large, blinded, randomized, placebo-controlled maintenance studies involving more than 3000 patients with bipolar I illness have been published, with analyses of background, symptomatic, and acute treatment factors contributing to maintenance effectiveness. This article summarizes these findings. Generally, indices of greater severity predict lower response rates to most monotherapy treatments. Some findings have been unexpected. Mixed mania did not predict different maintenance response to divalproex or lithium but predicted more side effects with either drug, and reduced efficacy of olanzapine or lamotrigine.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalCurrent psychiatry reports
Issue number6
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Psychiatry and Mental health


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