Relationship between functional castration and alpha fetoprotein produced by hepatoma bearing female rats

T. B. Pool, N. Hagino, I. L. Cameron

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

In rats bearing Morris hepatoma No. 7777, serum levels of alpha fetoprotein (AFP) increased as tumor size increased. Hepatoma-bearing females remained in diestrus once the tumor exceeded a cross-sectional area of 12 cm2. The following changes were seen in tumor-bearing rats compared to control animals: uterine wet weight was significantly decreased, the uterine epithelial mucosa was lower, castration cells developed in the anterior pituitary, and there was a 3- to 23-fold elevation in serum estrogen levels. The authors conclude that circulating estrogen is bound to AFP in hepatoma-bearing female rats and that in this bound state it is unable to exert its normal physiological actions.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalJournal of reproduction and fertility
Volume53
Issue number1
DOIs
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

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