Relationship Between Frequent Episodes of Peritonitis and Altered Immune Status

Sharon L. Lewis, Stephen A. Young, Barbara J. Wood, Kelly S. Morgan, Dale G. Erickson, Clifford J. Holmes

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    A 60-year-old Native American diabetic female patient had a history of nine episodes of peritonitis (both relapsing and persistent) during the year that she was treated with continuous ambulatory peritoneal dialysis (CAPD). At the start of CAPD the patient had an inverted CD4 to CD8 ratio that decreased from 0.97 to 0.50 in 1 year. This finding was due to a decrease in CD4+ cells and an increase in CD8+ cells that were also positive for CD57 (Leu-7) and HLADR (la) antigen, suggesting a state of activation. The serology indicated a cytomegalovirus immunoglobulin G titer of 1:2,048. The patient also had significantly increased natural killer cells. These alterations suggest the presence of a chronic viral infection that may have caused the patient to be immunosuppressed, thereby predisposing her to repeated episodes of peritonitis.

    Original languageEnglish (US)
    Pages (from-to)456-461
    Number of pages6
    JournalAmerican Journal of Kidney Diseases
    Volume22
    Issue number3
    DOIs
    StatePublished - 1993

    Keywords

    • Continuous ambulatory peritoneal dialysis
    • cytomegalovirus
    • immunosuppression
    • lymphocytes
    • peritonitis

    ASJC Scopus subject areas

    • Nephrology

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