Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment

Nidhi A. Shah, Nancy K. Hills, Nahid Waleh, Donald McCurnin, Steven Seidner, Sylvain Chemtob, Ronald Clyman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Objective: To determine whether low platelet counts are related to the incidence of patent ductus arteriosus (PDA) after indomethacin treatment in preterm human infants. Study design: Multivariable logistic regression modeling was used for a cohort of 497 infants, who received indomethacin (within 15 hours of birth). Results: Platelet counts were not related to the incidence of permanent closure after indomethacin constriction. There was a relationship between platelet counts and the initial degree of constriction; however, this relationship appeared to be primarily influenced by the high end of the platelet distribution curve. PDA incidence was similar in infants with platelet counts <50 ×109/L and those with platelet counts above this range. Only when platelet counts were consistently >230 ×109/L was there a decrease in PDA incidence. Conclusion: In contrast to the evidence in mice, low circulating platelet counts do not affect permanent ductus closure (or ductus reopening) in human preterm infants.

Original languageEnglish (US)
Pages (from-to)919-923.e2
JournalJournal of Pediatrics
Volume158
Issue number6
DOIs
StatePublished - Jun 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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